发明公开
- 专利标题： Central nervous system antiischemic agents
- 专利标题（中）： 中国人民解放军防盲联合会。
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申请号： EP93400565.3申请日： 1993-03-04
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公开(公告)号： EP0559569A1公开(公告)日： 1993-09-08
- 发明人: Poindexter, Graham S.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： 345 Park Avenue New York, N.Y. 10154 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： 345 Park Avenue New York, N.Y. 10154 US
- 代理机构： Durand, Yves Armand Louis
- 优先权： US847389 19920306
- 主分类号： C07C323/25
- IPC分类号： C07C323/25 ; C07C323/14 ; C07C323/41 ; C07C323/42 ; C07C31/28 ; A61K31/135 ; A61K31/165
摘要：
A series of phenylalkylaminoalkyl derivatives of Formula I
wherein Ar is naphtyl or phenyl;
R¹ is hydrogen, fluoro or R⁴CONH-;
R² is hydrogen or C₁ - ₆ alkyl;
R₃ is C₁ - ₆ alkyl;
R⁴ is C₁ - ₆ alkyl or phenyl- C₁ - ₆ alkyl;
x is zero or the integers 1 and 2;
m is selected from the integers 1 to 6; and
n is selected from the integers 2 and 3,
has been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma or stroke or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.
wherein Ar is naphtyl or phenyl;
R¹ is hydrogen, fluoro or R⁴CONH-;
R² is hydrogen or C₁ - ₆ alkyl;
R₃ is C₁ - ₆ alkyl;
R⁴ is C₁ - ₆ alkyl or phenyl- C₁ - ₆ alkyl;
x is zero or the integers 1 and 2;
m is selected from the integers 1 to 6; and
n is selected from the integers 2 and 3,
has been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma or stroke or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.
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