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公开(公告)号：EP4445958A3
公开(公告)日：2024-10-23
申请号：EP24182623.9
申请日：2019-10-18
发明人： MAURER, Matthew , SIMONSEN, Katy L.
IPC分类号： A61K39/395 , A61P35/00
摘要： The invention provides a method of treating a previously untreated metastatic or unresectable melanoma.
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公开(公告)号：EP4397675A3
公开(公告)日：2024-10-16
申请号：EP24163980.6
申请日：2013-09-12
发明人： CLOAD, Sharon , ENGLE, Linda , LIPOVSEK, Dasa , MADIREDDI, Malavi , RAKESTRAW, Ginger, Chao , SWAIN, Joanna F. , ZHAO, Wenjun , WEI, Hui , YAMNIUK, Aaron, P. , KOZHICH, Alexander, T. , RAMAMURTHY, Vidhyashankar , CORBETT, Martin, J. , KRYSTEK, Stanley, Richard, Jr.
IPC分类号： C07K14/435
摘要： The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.
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公开(公告)号：EP4423094A1
公开(公告)日：2024-09-04
申请号：EP22813058.9
申请日：2022-10-28
发明人： PINTO, Donald J.P. , SU, Shun , MATHUR, Arvind , MYERS, Michael C. , LI, Jianqing , PABBISETTY, Kumar Balashanmuga , SHAW, Scott A.
IPC分类号： C07D498/04 , C07C235/40 , C07C275/34 , A61K31/42 , A61P9/10
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公开(公告)号：EP4404930A1
公开(公告)日：2024-07-31
申请号：EP22792963.5
申请日：2022-09-22
IPC分类号： A61K31/501 , A61K31/506 , A61P17/14 , A61K9/00
CPC分类号： A61K31/501 , A61K31/506 , A61P17/14 , A61K9/0053 , A61K9/0014
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公开(公告)号：EP4344695A3
公开(公告)日：2024-06-05
申请号：EP24157510.9
申请日：2019-05-10
CPC分类号： A61J1/20 , A61J1/2058 , A61J1/2068 , A61J1/2089 , A61J3/002 , A61M5/1408 , A61M5/1409 , A61J1/16 , A61M5/14248 , A61M2005/1426820130101 , A61M2209/04520130101 , A61M5/1413
摘要： In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.
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6.发明公开
公开(公告)号：EP4373839A1
公开(公告)日：2024-05-29
申请号：EP22846765.0
申请日：2022-07-18
发明人： CUI, Honggang , LI, Yi , STERN, David , XU, XuanKuo , LOCK, Lye, Lin , MILLS, Jason , GHOSE, Sanchayita , LI, Zheng Jian
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公开(公告)号：EP4364737A2
公开(公告)日：2024-05-08
申请号：EP24159615.4
申请日：2021-10-18
发明人： LUO, Guanglin , CHEN, Jie , DZIERBA, Carolyn Diane , FRENNESSON, David B. , GUO, Junqing , HART, Amy C. , HU, Xirui , MERTZMAN, Michael E. , PATTON, Matthew Reiser , SHI, Jianliang , SPERGEL, Steven H. , VENABLES, Brian Lee , WU, Yong-Jin , XIAO, Zili , YANG, Michael G.
IPC分类号： A61K31/444
CPC分类号： C07D471/04 , A61P29/00 , A61P9/04 , A61P17/06 , A61P25/28
摘要： Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
8.发明公开
公开(公告)号：EP4359438A1
公开(公告)日：2024-05-01
申请号：EP22738290.0
申请日：2022-06-17
发明人： BINDRA, Dilbir Singh , DEAR, Barton J. , HU, Yue , MONDAL SIERRA, Ismahr-ehl , MORE, Haresh Tukaram , PAN, Duohai , WU, Yongmei
IPC分类号： C07K16/28 , A61K39/395 , A61K9/19 , A61K47/26
CPC分类号： C07K16/2818 , C07K2317/7420130101 , C07K2319/0020130101 , C07K2319/5020130101 , A61K39/39591 , C07K2317/9020130101 , A61K9/19 , A61K47/26 , A61K47/183 , A61K9/0019
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公开(公告)号：EP4334308A1
公开(公告)日：2024-03-13
申请号：EP22728999.8
申请日：2022-05-04
发明人： WANG, Tao , ZHANG, Zhongxing , YIN, Zhiwei
IPC分类号： C07D403/12 , C07D403/14 , C07D407/12 , C07D407/14 , A61K31/44 , A61K31/445 , A61P35/00 , C07D413/14
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公开(公告)号：EP4320125A1
公开(公告)日：2024-02-14
申请号：EP22719432.1
申请日：2022-04-04
发明人： KUMI, Godwin Kwame , PURANDARE, Ashok Vinayak , LI, Guo , SHAN, Weifang , BALOG, James Aaron , CHERNEY, Emily Charlotte , CHEN, Yan
IPC分类号： C07D471/08 , A61P31/12 , A61P35/00 , C07D401/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/08 , C07D498/10 , A61K31/445
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