发明公开
EP0573107A3 Process for attenuated varicella zoster virus vaccine production
失效
一种用于生产减毒水痘 - 带状疱疹病毒病毒疫苗的过程。
- 专利标题： Process for attenuated varicella zoster virus vaccine production
- 专利标题（中）： 一种用于生产减毒水痘 - 带状疱疹病毒病毒疫苗的过程。
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申请号： EP93201521.7申请日： 1993-05-27
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公开(公告)号： EP0573107A3公开(公告)日： 1995-04-26
- 发明人: Provost, Phillip J. , Krah, David L. , Friedman, Paul A.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Quillin, Helen Kaye
- 优先权： US893295 19920604; US894039 19920604
- 主分类号： A61K39/25
- IPC分类号： A61K39/25
摘要：
A live, attenuated varicella zoster virus vaccine is produced with enhanced yield of VZV. The new process makes mass production of a live VZV vaccine more practical. In addition, optimized monolayer cell culture conditions provide a process for maximizing monolayer cell density which is useful for enhancing viral vaccine production. According to this process, cell densities approaching 500,000 cells/cm² are routinely achieved in conventional culture vessels.
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