公开(公告)号：EP2400950B1

公开(公告)日：2019-05-22

申请号：EP09779096.8

申请日：2009-02-26

申请人： Glaxo Group Limited

发明人： BAKER, Darrell ,  BRUCE, Mark ,  THOMAS, Marian

IPC分类号： A61K9/00 ,  A61K31/138 ,  A61K31/58 ,  A61K45/06 ,  A61P11/08

公开(公告)号：EP1261328B1

公开(公告)日：2005-07-20

申请号：EP01914603.4

申请日：2001-03-01

申请人： SmithKline Beecham Corporation

发明人： PALOVICH, Michael, R. ,  WEINSTOCK, Joseph ,  WIDDOWSON, Katherine, L.

IPC分类号： A61K31/135 ,  C07C13/06

CPC分类号： A61K31/135 ,  C07C225/20 ,  C07C255/59 ,  C07C2601/04 ,  Y02A50/411

摘要： This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

公开(公告)号：EP1265905A1

公开(公告)日：2002-12-18

申请号：EP01916312.0

申请日：2001-03-01

申请人： SmithKline Beecham Corporation

发明人： PALOVICH, Michael, R. ,  WEINSTOCK, Joseph ,  WIDDOWSON, Katherine, L.

IPC分类号： C07F9/02

CPC分类号： C07F9/247

摘要： This invention relates to the novel use of diphenyl phosphonates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

公开(公告)号：EP1261336A2

公开(公告)日：2002-12-04

申请号：EP01918542.0

申请日：2001-03-09

申请人： SmithKline Beecham Corporation

发明人： WIDDOWSON, Katherine, L. ,  JIN, Qi

IPC分类号： A61K31/415 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/4365 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/513 ,  C07D213/74 ,  C07D213/75 ,  C07D231/38 ,  C07D231/40 ,  C07D237/20 ,  C07D249/06 ,  C07D261/02 ,  C07D261/04 ,  C07D497/04

CPC分类号： C07D213/75 ,  C07D213/89 ,  C07D231/40 ,  C07D249/04 ,  C07D249/14 ,  C07D261/14 ,  C07D495/04

摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

公开(公告)号：EP1233768A1

公开(公告)日：2002-08-28

申请号：EP00979160.9

申请日：2000-11-13

申请人： Smithkline Beecham

发明人： FRANCHINI, Miriam ,  VENKATESH, Gopadi, M.

IPC分类号： A61K31/403 ,  C07D209/88

CPC分类号： A61K9/2054 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/5078 ,  A61K31/403 ,  C07D209/88

摘要： This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.

摘要翻译： 本发明涉及卡维地洛甲磺酸盐，含有该化合物的组合物以及使用卡维地洛甲磺酸盐治疗高血压，充血性心力衰竭和心绞痛的方法。

公开(公告)号：EP0573107B1

公开(公告)日：2001-10-04

申请号：EP93201521.7

申请日：1993-05-27

申请人： Merck & Co., Inc.

发明人： Provost, Phillip J. ,  Krah, David L. ,  Friedman, Paul A.

IPC分类号： A61K39/25

CPC分类号： C12N5/0018 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C12N2500/36 ,  C12N2710/16734 ,  Y02A50/466

摘要： A process for culturing cells in monolayer which comprises : a. seeding a culture vessel with a cell stock in a minimal or rich medium and allowing the cells to plant for about 24-72 hours; b. removing the medium from the culture of step a. and replacing with fresh, rich medium, supplemented with an opitimized concentration of lipids and optionally also including a serum supplement; c. growing the culture of cells in rich medium supplemented with lipid; d . optionally replacing the medium of Step c. with fresh medium containing no lipid supplement, after about 24-72 hours growth.

公开(公告)号：EP0577394B1

公开(公告)日：1999-11-10

申请号：EP93305086.6

申请日：1993-06-29

申请人： Merck & Co., Inc.

发明人： Dorn, Conrad P. ,  Hale, Jeffrey J. ,  Maccoss, Malcolm ,  Mills, Sander G. ,  Ladduwahetty, Tamara ,  Shah, Shrenik K.

IPC分类号： C07D265/32 ,  C07D265/30 ,  C07D279/12 ,  C07D413/06 ,  A61K31/535

CPC分类号： C07D265/30 ,  C07D265/32 ,  C07D279/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14

公开(公告)号：EP0578723B1

公开(公告)日：1999-06-09

申请号：EP92908427.5

申请日：1992-03-09

申请人： Merck & Co., Inc.

发明人： HAYTKO, Peter, N. ,  WILDMAN, Arthur, S., Jr.

IPC分类号： B01D15/08 ,  C07D309/30

CPC分类号： A61K31/785 ,  A61K31/22 ,  A61K31/365 ,  A61K31/455 ,  A61K45/06 ,  B01D15/322 ,  B01D15/325 ,  Y10S514/824 ,  A61K31/19 ,  A61K31/095 ,  A61K2300/00

摘要： A process for the purification of an HMG-CoA reductase inhibitor employing preparative high performance liquid chromatography as well as a pharmaceutical composition comprising the HMG-CoA reductase inhibitor and pharmaceutically acceptable carrier.

公开(公告)号：EP0820279A1

公开(公告)日：1998-01-28

申请号：EP96911710.0

申请日：1996-04-10

申请人： GLAXO WELLCOME INC.

发明人： ASHURST, Ian, C. ,  HERMAN, Craig, S. ,  LI-BOVET, Li ,  RIEBE, Michael, T.

IPC分类号： A61K9 ,  A61K31 ,  A61M15 ,  A61P11 ,  B05D5 ,  B05D7 ,  B65D83

CPC分类号： A61K9/008 ,  A61K9/124 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/009 ,  A61M2205/0222 ,  B65D83/54 ,  A61K31/135 ,  A61K2300/00

摘要： A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising albuterol or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.

公开(公告)号：EP0757684A1

公开(公告)日：1997-02-12

申请号：EP95918579.0

申请日：1995-04-21

申请人： GLAXO GROUP LIMITED

发明人： GOODYEAR, Michael, David Glaxo R. & D. Limited, ,  DWYER, P., Owen Glaxo Research and Development Ltd ,  HILL, Malcolm, Leithead Glaxo Research and ,  WHITEHEAD, Andrew, Jonathan Glaxo Research and ,  HORNBY, Roy Glaxo Research and Development Limited ,  HALLETT, Peter Glaxo Research and Development Ltd

IPC分类号： C07D ,  C07D327 ,  C07D339 ,  C07D411 ,  C07D473

CPC分类号： C07D473/00 ,  C07D327/04 ,  C07D411/04

摘要： A diastereoselective process for the preparation of compounds of formula (I), wherein W is S, S=O, SO2, or O; X is S, S=O, SO2, or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof, is described.