发明公开
- 专利标题： Recombinant human HIV-neutralizing monoclonal antibodies for prevention and treatment of HIV infection
- 专利标题（中）： HIV中和HIV感染的治疗和预防的重组抗体。
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申请号： EP93302546.2申请日： 1993-03-31
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公开(公告)号： EP0577243A2公开(公告)日： 1994-01-05
- 发明人: Emini, Emilio A. , Conley, Anthony J. , Mark, George E. , Johnson, L. Syd , Pfarr, David S.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Quillin, Helen Kaye
- 优先权： US861701 19920401
- 主分类号： C12N15/13
- IPC分类号： C12N15/13 ; C12P21/08 ; C12N5/10 ; A61K39/395
摘要：
Recombinant human immunoglobulin molecules neutralizing for HIV-1, methods of production of the immunoglobulins and methods of preventing HIV-1 infection using the immunoglobulins are disclosed. DNA constructs containing the complementarity determining regions (CDRs) and framework (FRs) of the native human antibody are combined with other constant regions, and expressed in recombinant host cells. These recombinant antibodies are useful for the treatment and prevention of HIV-1 infection in vivo .
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