发明授权
- 专利标题： CHIMERIC AND/OR GROWTH-RESTRICTED FLAVIVIRUSES
- 专利标题（中）： 嵌合和/或生长抑制黄病毒
-
申请号： EP92920708.2申请日： 1992-09-18
-
公开(公告)号： EP0604566B1公开(公告)日： 1999-11-17
- 发明人: LAI, Ching-Juh , BRAY, Michael , PLETNEV, Alexander, G. , MEN, Ruhe , CHANOCK, Robert, M.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： 200 Independence Avenue Washington, DC 20201 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： 200 Independence Avenue Washington, DC 20201 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US761222 19910919; US761224 19910919
- 国际公布： WO9306214 19930401
- 主分类号： C12N15/40
- IPC分类号： C12N15/40 ; C12N7/01 ; C12N1/20 ; A61K39/12
摘要：
The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus.
信息查询
IPC分类:
