专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"PLETNEV, Alexander, G." 第 1 页

1.

发明公开
CHIMERIC AND/OR GROWTH-RESTRICTED FLAVIVIRUSES 失效
标题翻译：嵌合和/或生长抑制黄病毒。

公开(公告)号：EP0604566A1

公开(公告)日：1994-07-06

申请号：EP92920708.0

申请日：1992-09-18

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： LAI, Ching-Juh , BRAY, Michael , PLETNEV, Alexander, G. , MEN, Ruhe , PETHEL, Michele

IPC分类号： C12N15 , A61K31 , A61K39 , A61P31 , C07K14 , C12N1 , C12N7 , C12R1

CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K2039/522 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C12N2710/14143 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24322 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396

摘要： The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus.

2.

发明授权
CHIMERIC AND/OR GROWTH-RESTRICTED FLAVIVIRUSES 失效
标题翻译：嵌合和/或生长抑制黄病毒

公开(公告)号：EP0604566B1

公开(公告)日：1999-11-17

申请号：EP92920708.2

申请日：1992-09-18

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： LAI, Ching-Juh , BRAY, Michael , PLETNEV, Alexander, G. , MEN, Ruhe , CHANOCK, Robert, M.

IPC分类号： C12N15/40 , C12N7/01 , C12N1/20 , A61K39/12

CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K2039/522 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C12N2710/14143 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24322 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396

摘要： The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus.