发明授权
EP0607355B1 3-UREIDO-BENZODIAZEPINONES UTILES COMME ANTAGONISTES DE CCK OU DE GASTRINE
失效
3-脲苯并二氮杂有用AS CCK或胃泌素拮抗剂。
- 专利标题: 3-UREIDO-BENZODIAZEPINONES UTILES COMME ANTAGONISTES DE CCK OU DE GASTRINE
- 专利标题(英): 3-ureido-benzodiazepinones useful as antagonists of cck or of gastrine
- 专利标题(中): 3-脲苯并二氮杂有用AS CCK或胃泌素拮抗剂。
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申请号: EP92922727.0申请日: 1992-10-08
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公开(公告)号: EP0607355B1公开(公告)日: 1995-11-22
- 发明人: CAPET, Marc , COTREL, Claude , DUBRUCQ, Marie-Christine , GUYON, Claude , MARTIN, Jean-Paul
- 申请人: RHONE-POULENC RORER S.A.
- 申请人地址: 20, avenue Raymond Aron 92160 Antony FR
- 专利权人: RHONE-POULENC RORER S.A.
- 当前专利权人: RHONE-POULENC RORER S.A.
- 当前专利权人地址: 20, avenue Raymond Aron 92160 Antony FR
- 代理机构: Savina, Jacques
- 优先权: FR9112481 19911010
- 国际公布: WO9307130 19930415
- 主分类号: C07D243/24
- IPC分类号: C07D243/24 ; C07D405/12 ; C07D403/12 ; C07D401/04 ; C07F9/645 ; A61K31/55 ; A61K31/675
摘要:
Compounds having formula (I), wherein R1 is a hydrogen or halogen atom or an alkyl, alcoxy, alkylthio, nitro, hydroxy or cyano radical; R2 is an alkyl radical or a chain -CH(R5)-CO-R6; R3 is (a) a phenyl radical substituted by one or a plurality of substituants selected amongst the radicals -alk-SO3H, -alk-PO3H2, -CH=NOH, -CH=NO-alk-COOX, -S-alk-COOX, -SO-alk-COOX, -SO2-alk-COOX, -CH=CH-COOX, -alk-CO-NHOH, -C(=NOH)-COOX, -alk-N(OH)-CO-alk, -alk-SO2H, -CH=CH-SO3H, -C(COOX)=N-O-alk-COOX, tetrazolylalkyle or a group having the formula (1) or (b) a ring having the formula (A) wherein R9 is a radical =NOX, =NO-alk-COOX, =CH-COOX, -alk-COOX, -alk-SO2H or -alk-SO3H, R10 is an oxygen or sulfur atom or a methylene or alkylimino radical and R11 is a methylene or ethylene radical, R4 is a pyridyle or phenyl radical optionally substituted by one or a plurality of substitutants selected amongst halogen atoms or the alkyl, alcoxy, hydroxy, carboxy, nitro and -CO-NR6 radicals, alk is an alkyl or alkylene radical and X is a hydrogen atom or an alkyl radical. The invention also discloses the salts thereof, their preparation and medicaments containing them.
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