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1.发明授权3-UREIDO-BENZODIAZEPINONES UTILES COMME ANTAGONISTES DE CCK OU DE GASTRINE 失效3-脲苯并二氮杂有用AS CCK或胃泌素拮抗剂。
公开(公告)号：EP0607355B1
公开(公告)日：1995-11-22
申请号：EP92922727.0
申请日：1992-10-08
IPC分类号： C07D243/24 , C07D405/12 , C07D403/12 , C07D401/04 , C07F9/645 , A61K31/55 , A61K31/675
CPC分类号： C07D401/04 , C07D243/24 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds having formula (I), wherein R1 is a hydrogen or halogen atom or an alkyl, alcoxy, alkylthio, nitro, hydroxy or cyano radical; R2 is an alkyl radical or a chain -CH(R5)-CO-R6; R3 is (a) a phenyl radical substituted by one or a plurality of substituants selected amongst the radicals -alk-SO3H, -alk-PO3H2, -CH=NOH, -CH=NO-alk-COOX, -S-alk-COOX, -SO-alk-COOX, -SO2-alk-COOX, -CH=CH-COOX, -alk-CO-NHOH, -C(=NOH)-COOX, -alk-N(OH)-CO-alk, -alk-SO2H, -CH=CH-SO3H, -C(COOX)=N-O-alk-COOX, tetrazolylalkyle or a group having the formula (1) or (b) a ring having the formula (A) wherein R9 is a radical =NOX, =NO-alk-COOX, =CH-COOX, -alk-COOX, -alk-SO2H or -alk-SO3H, R10 is an oxygen or sulfur atom or a methylene or alkylimino radical and R11 is a methylene or ethylene radical, R4 is a pyridyle or phenyl radical optionally substituted by one or a plurality of substitutants selected amongst halogen atoms or the alkyl, alcoxy, hydroxy, carboxy, nitro and -CO-NR6 radicals, alk is an alkyl or alkylene radical and X is a hydrogen atom or an alkyl radical. The invention also discloses the salts thereof, their preparation and medicaments containing them.
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2.发明授权
公开(公告)号：EP0593639B1
公开(公告)日：1995-04-05
申请号：EP92915456.5
申请日：1992-07-03
发明人： CAPET, Marc , COTREL, Claude , GUYON, Claude , JOANNIC, Michel , MANFRE, Franco , ROUSSEL, Gérard , DUBROEUCQ, Marie-Christine , CHEVE, Michel , DUTRUC-ROSSET, Gilles
IPC分类号： C07D207/06 , C07K5/06 , A61K31/40 , A61K38/00 , C07B57/00
CPC分类号： C07K5/06026 , A61K38/00 , C07D207/06 , C07K1/16
摘要： Compounds of formule (I), salts thereof, the preparation thereof, and drugs containing same.
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3.发明公开3-UREIDO-BENZODIAZEPINONES UTILES COMME ANTAGONISTES DE CCK OU DE GASTRINE 失效3-脲苯并二氮杂有用AS CCK或胃泌素拮抗剂。
公开(公告)号：EP0607355A1
公开(公告)日：1994-07-27
申请号：EP92922727.0
申请日：1992-10-08
CPC分类号： C07D401/04 , C07D243/24 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Composés de formule (I) dans laquelle R1 représente un atome d'hydrogène ou d'halogène ou un radical alkyle, alcoxy, alkylthio, nitro, hydroxy ou cyano; R2 représente un radical alkyle ou une chaîne -CH(R5)-CO-R6; R3 représente (a) un radical phényle substitué par un ou plusieurs substituants choisis parmi les radicaux -alk-SO3H, -alk-PO3H2, -CH=NOH, -CH=NO-alk-COOX, -S-alk-COOX, -SO-alk-COOX, -SO2-alk-COOX, -CH=CH-COOX, -alk-CO-NHOH, -C(=NOH)-COOX, -alk-N(OH)-CO-alk, -alk-SO2H, -CH=CH-SO3H, -C(COOX)=N-O-alk-COOX, tétrazolylalkyle ou un groupe de formule (1) ou (b) un cycle de formule (A) dans laquelle R9 représente un radical =NOX, =NO-alk-COOX, =CH-COOX, -alk-COOX, -alk-SO2H ou -alk-SO3H, R10 représente un atome d'oxygène ou de soufre ou un radical méthylène ou alkylimino et R11 représente un radical méthylène ou éthylène, R4 représente un radical pyridyle ou phényle éventuellement substitué par un ou plusieurs substituants choisis parmi les atomes d'halogène et les radicaux alkyle, alcoxy, hydroxy, carboxy, nitro et -CO-NR6, alk représente un radical alkyle ou alkylène et X représente un atome d'hydrogène ou un radical alkyle; leurs sels, leur préparation et les médicaments les contenant.
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公开(公告)号：EP0766696A1
公开(公告)日：1997-04-09
申请号：EP95923409.0
申请日：1995-06-19
CPC分类号： C07K5/06034 , A61K38/00 , C07K5/06026 , C07K5/06191
摘要： Thiazolidine derivatives of formula (I), in which R1, R2, R3, R4 and R5 are as defined in the specification. The invention also concerns the salts of these derivatives, the preparation thereof and drugs containing same.
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公开(公告)号：EP0766696B1
公开(公告)日：1998-09-02
申请号：EP95923409.7
申请日：1995-06-19
CPC分类号： C07K5/06034 , A61K38/00 , C07K5/06026 , C07K5/06191
摘要： Thiazolidine derivatives of formula (I), in which R1, R2, R3, R4 and R5 are as defined in the specification. The invention also concerns the salts of these derivatives, the preparation thereof and drugs containing same.
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公开(公告)号：EP0520016B1
公开(公告)日：1994-10-05
申请号：EP91906784.3
申请日：1991-03-11
发明人： BOURZAT, Jean-Dominique , CAPET, Marc , COTREL, Claude , GUYON, Claude , MANFRE, Franco , ROUSSEL, Gérard
IPC分类号： C07C275/28 , C07C273/18 , A61K31/17
CPC分类号： C07C323/44 , C07C275/28 , C07C275/30 , C07C275/34
摘要： Compounds of the formula (I) in which R1 is an alkyl radical, R2 is a phenyl radical or a -(CH2)m-CO-R4 chain in which m is O, 1 or 2 and R4 is a hydroxy, alkoxy or amino radical, R3 is a hydrogen atom or an alkyl, alkoxy or alkylthio radical, n is O or 1, their preparation and the medicaments containing them.
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7.发明授权DERIVES DE N-PHENYL GLYCINAMIDE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效N-苯基甘氨酸衍生物，生产和DRUGS它们含有。
公开(公告)号：EP0518960B1
公开(公告)日：1994-09-14
申请号：EP91905832.1
申请日：1991-03-05
发明人： BOURZAT, Jean-Dominique , CAPET, Marc , COTREL, Claude , GUYON, Claude , MANFRE, Franco , ROUSSEL, Gérard
CPC分类号： C07K5/06026 , A61K38/00
摘要： Compounds of the formula (I) in which: R1 is a hydrogen atom, an alkyl, alkoxycarbonyl or optionally substituted phenyl radical; R2 is an alkoxy, optionally substituted cycloalkyloxy, cycloalkyloxy, phenylalkyloxy, polyfluoroalkyloxy, cinnamyloxy, -NR5R6 radical; R3 is a phenylamino radical in which the phenyl nucleus may be substituted, optionally substituted phenyl, naphthyl, indolyl or quinolyl; R4 is a substituted phenyl radical; R5 and R6 are identical or different and represent a hydrogen atom, an alkyl, optionally substituted phenyl, indanyl, cycloalkylalkyl, cycloalkyl, phenylalkyl radical or R5 and R6 together with the nitrogen atom to which they are linked form a heterocycle; their preparation and the medicaments containing them.
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8.发明授权N-PHENYL N-ALCOXYCARBONYLALKYLE GLYCINAMIDES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效的N-苯基-N-烷氧基羰基 - 甘氨酸酰胺，生产和含有药物。
公开(公告)号：EP0516729B1
公开(公告)日：1993-12-29
申请号：EP91905298.5
申请日：1991-02-14
发明人： BOURZAT, Jean-Dominique , CAPET, Marc , COTREL, Claude , GUYON, Claude , MANFRE, Franco , ROUSSEL, Gérard
IPC分类号： C07K5/06 , A61K37/02 , C07C275/28
CPC分类号： C07C275/28
摘要： Compounds of formula (I), wherein R1 represents a hydrogen atom or a substituted or unsubstituted alkyl, alkyoxycarbonyl or phenyl radical; R2 represents a substituted or unsubstituted alkyl (C1-8), polyfluoroalkyl or cycloalkyl radical; R3 represents a naphthyl-, indolyl-, quinolyl-, phenylamino-substituted or -unsubstituted phenyl radical, wherein the phenyl core is optionally substituted, or a quinolylamino radical; m is 0 or 1. Methods for preparing said compounds and drugs containing them are also described.
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9.发明公开N-PHENYL N-ALCOXYCARBONYLALKYLE GLYCINAMIDES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效的N-苯基-N-烷氧基羰基 - 甘氨酸酰胺，生产和含有药物。
公开(公告)号：EP0516729A1
公开(公告)日：1992-12-09
申请号：EP91905298.0
申请日：1991-02-14
发明人： BOURZAT, Jean-Dominique , CAPET, Marc , COTREL, Claude , GUYON, Claude , MANFRE, Franco , ROUSSEL, Gérard
IPC分类号： A61K31 , A61K38 , A61P1 , A61P3 , A61P21 , A61P25 , A61P35 , C07C237 , C07C275 , C07C323 , C07D209 , C07D215 , C07K1 , C07K5
CPC分类号： C07C275/28
摘要： Composés de formule (I) dans laquelle R1 représente un atome d'hydrogène ou un radical alkyle, alcoxycarbonyle ou phényle non substitué ou substitué, R2 représente un radical alkyle (1-8C), polyfluoroalkyle ou cycloalkyle non substitué ou substitué, R3 représente un radical phényle non substitué ou substitué naphtyle, indolyle, quinolyle, phénylamino dont le noyau phényle est éventuellement substitué ou un radical quinolylamino, m est égal à 0 ou 1, leurs procédés de préparation et les médicaments les contenant.
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10.发明公开
公开(公告)号：EP0879054A1
公开(公告)日：1998-11-25
申请号：EP97904476.0
申请日：1997-02-03
发明人： BOHME, Andrees , DUBROEUCQ, Marie-Christine , FRATTA, Walter , GUYON, Claude , IMPERATO, Assunta , MANFRE, Franco
IPC分类号： A61K31
CPC分类号： A61K31/426 , A61K31/40 , A61K31/401
摘要： Application of pyrrolidine derivatives having general formula (I), racemic compounds and enantiomers thereof when they contain one or a plurality of asymmetrical centers, and salts thereof, to the preparation of medicaments intended to the treatment of abuses of drugs or substances giving rise to pharmacomania or to an excessive use with the exception of alcohol abuse.
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