发明公开
EP0609587A2 Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
失效
碘苯氧基亚油酸和碘苯醚 - Zusammensetzungen在schichtbildenden MateralienfürBildformung des Gastrointestinaltraktes。
- 专利标题： Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
- 专利标题（中）： 碘苯氧基亚油酸和碘苯醚 - Zusammensetzungen在schichtbildenden MateralienfürBildformung des Gastrointestinaltraktes。
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申请号： EP93203675.9申请日： 1993-12-24
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公开(公告)号： EP0609587A2公开(公告)日： 1994-08-10
- 发明人: Illig, Carl R., c/o Sterling Winthrop Inc. , Cooper, Eugene R., c/o Sterling Winthrop Inc. , Toner, John L., c/o Sterling Winthrop Inc. , Upson, Donald, c/o Sterling Winthrop Inc. , Douty, Brent D., c/o Sterling Winthrop Inc. , Caulfield, Thomas J., c/o Sterling Winthrop Inc. , Bacon, Edward R., c/o Sterling Winthrop Inc. , Estep, Kimberley G., c/o Sterling Winthrop Inc. , Josef, Kurt A., c/o Sterling Winthrop Inc. , Robinson, Shaughnessey, c/o Sterling Winthrop Inc. , Spara, Paul P., c/o Sterling Winthrop Inc.
- 申请人： NYCOMED IMAGING AS
- 申请人地址： Nycoveien 2, N-0485 Oslo NO
- 专利权人： NYCOMED IMAGING AS
- 当前专利权人： NYCOMED IMAGING AS
- 当前专利权人地址： Nycoveien 2, N-0485 Oslo NO
- 代理机构： Woodman, Derek
- 优先权： US12171 19930202
- 主分类号： A61K49/04
- IPC分类号： A61K49/04
摘要：
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing
agent of the formula
or a pharmaceutically acceptable salt thereof,
and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R = C 1 -C 25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy lower-alkoxycarbonyl or lower-alkoxy-carbonyloxy, (CR 1 R 2 ) p -CR 3 =CR 4 ) m Q, or (CR, R 2 )p-C=C-Q;
Ri, R 2 , R 3 and R 4 are independently lower-alkyl, optionally substituted with halo;
x is 1-4;
n is 1-5;
m is 1-15;
p is 1-10; and
Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl
in a pharmaceutically acceptable carrier.
agent of the formula
or a pharmaceutically acceptable salt thereof,
and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R = C 1 -C 25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy lower-alkoxycarbonyl or lower-alkoxy-carbonyloxy, (CR 1 R 2 ) p -CR 3 =CR 4 ) m Q, or (CR, R 2 )p-C=C-Q;
Ri, R 2 , R 3 and R 4 are independently lower-alkyl, optionally substituted with halo;
x is 1-4;
n is 1-5;
m is 1-15;
p is 1-10; and
Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl
in a pharmaceutically acceptable carrier.
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