发明公开
- 专利标题： Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract
- 专利标题（中）： 碘化苯酯和磺酸钠Zusammensetzungen在电影产品中。
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申请号： EP94200842.6申请日： 1994-03-29
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公开(公告)号： EP0617970A2公开(公告)日： 1994-10-05
- 发明人: Bacon, Edward R., c/o STERLING WINTHROP INC. , Daum, Sol J., c/o STERLING WINTHROP INC. , Estep, Kimberley G. c/o STERLING WINTHROP INC. , Josef, Kurt A., c/o STERLING WINTHROP INC. , Douty, Brent D., c/o STERLING WINTHROP INC. , Illig, Carl R., c/o STERLING WINTHROP INC.
- 申请人： NYCOMED IMAGING AS
- 申请人地址： Nycoveien 2, N-0485 Oslo NO
- 专利权人： NYCOMED IMAGING AS
- 当前专利权人： NYCOMED IMAGING AS
- 当前专利权人地址： Nycoveien 2, N-0485 Oslo NO
- 代理机构： Woodman, Derek
- 优先权： US40702 19930331
- 主分类号： A61K49/04
- IPC分类号： A61K49/04
摘要：
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract, said polymeric material having atoms containing polarizable electrons thereon, in combination with a divalent cation; and an x-ray contrast producing agent of the formula
or a pharmaceutically accetable salt thereof,
wherein
X =
or
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R = C 1 -C 25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,
n is 1-5;
y is 0-4; and
w is 1-4,
in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.
or a pharmaceutically accetable salt thereof,
wherein
X =
or
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R = C 1 -C 25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,
n is 1-5;
y is 0-4; and
w is 1-4,
in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.
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