发明公开
EP0622361A1 Heterocyclic compounds as bradykinin antagonists
失效
Heterocyclische Verbindungen als缓激肽拮抗剂。
- 专利标题： Heterocyclic compounds as bradykinin antagonists
- 专利标题（中）： Heterocyclische Verbindungen als缓激肽拮抗剂。
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申请号： EP94106486.7申请日： 1994-04-26
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公开(公告)号： EP0622361A1公开(公告)日： 1994-11-02
- 发明人: Oku, Teruo , Kayakiri, Hiroshi , Satoh, Shigeki , Abe, Yoshito , Sawada, Yuki , Inoue, Takayuki , Tanaka,Hirokazu
- 申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址： 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541 JP
- 专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541 JP
- 代理机构： Türk, Gille, Hrabal, Leifert
- 优先权： GB9308804 19930428; GB9318929 19930913
- 主分类号： C07D257/00
- IPC分类号： C07D257/00 ; C07D215/26 ; A61K31/395 ; C07D401/12 ; C07D409/12 ; C07D403/12 ; C07D241/42 ; C07D237/28 ; C07F7/18 ; C07K5/06 ; C07D239/86 ; C07D401/14 ; C07D405/12 ; C07D405/14
摘要：
A compound of the formula :
wherein
X¹ is N or C-R⁶,
X² is N or C-R⁷,
X³ is N or C-R⁸,
R¹ is hydrogen or halogen,
R² is halogen,
R³ is hydrogen, nitro, amino optionally having suitable substituent(s) or a heterocyclic group optionally having suitable substituent(s),
R⁴ and R⁵ are each hydrogen or halogen,
R⁶ and R⁸ are each hydrogen, halogen, lower alkyl, hydroxy, lower alkylthio, amino optionally substituted with lower alkyl, or lower alkoxy optionally substituted with a substituent selected from the group consisting of hydroxy, lower alkoxy, amino, lower alkylamino and aryl optionally substituted with lower alkoxy,
R⁷ is hydrogen or lower alkyl,
A is lower alkylene, and
Q is O or N-R⁹, in which R⁹ is hydrogen or
acyl, provided that R³ is not hydrogen when X¹ is C-R⁶, in which R⁶ is hydrogen,
and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.
wherein
X¹ is N or C-R⁶,
X² is N or C-R⁷,
X³ is N or C-R⁸,
R¹ is hydrogen or halogen,
R² is halogen,
R³ is hydrogen, nitro, amino optionally having suitable substituent(s) or a heterocyclic group optionally having suitable substituent(s),
R⁴ and R⁵ are each hydrogen or halogen,
R⁶ and R⁸ are each hydrogen, halogen, lower alkyl, hydroxy, lower alkylthio, amino optionally substituted with lower alkyl, or lower alkoxy optionally substituted with a substituent selected from the group consisting of hydroxy, lower alkoxy, amino, lower alkylamino and aryl optionally substituted with lower alkoxy,
R⁷ is hydrogen or lower alkyl,
A is lower alkylene, and
Q is O or N-R⁹, in which R⁹ is hydrogen or
acyl, provided that R³ is not hydrogen when X¹ is C-R⁶, in which R⁶ is hydrogen,
and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.
公开/授权文献
- EP0622361B1 Heterocyclic compounds as bradykinin antagonists 公开/授权日：2001-10-04
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