发明公开
EP0640075A1 CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS
失效
某些氨基甲基PHENYLIMIDAZOLDERIVATE,作者在特定配体多巴胺受体的新类。
- 专利标题: CERTAIN AMINOMETHYL PHENYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS
- 专利标题(中): 某些氨基甲基PHENYLIMIDAZOLDERIVATE,作者在特定配体多巴胺受体的新类。
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申请号: EP92903112.0申请日: 1991-12-23
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公开(公告)号: EP0640075A1公开(公告)日: 1995-03-01
- 发明人: THURKAUF, Andrew, Y. , HUTCHISON, Alan, J.
- 申请人: NEUROGEN CORPORATION
- 申请人地址: 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人: NEUROGEN CORPORATION
- 当前专利权人: NEUROGEN CORPORATION
- 当前专利权人地址: 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构: Eyles, Christopher Thomas
- 优先权: US19900635256 19901228
- 国际公布: WO1992012134 19920723
- 主分类号: A61K31
- IPC分类号: A61K31 ; A61P25 ; C07D233 ; C07D401 ; C07D403
摘要:
This invention encompasses compounds of formulas (I), where R1, R3, R4, R6, X, Y, and Z and T are variables; and M is α or β, where R2 is a variable; or R1 and R2 together may represent -(CH2)n1 where n1 is 1, 2, or 3. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.
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