A 4-amino(alkyl)cyclohexane-1-carboxamide compound represented by general formula (I), an isomer thereof, and a pharmaceutically acceptable acid addition salt thereof, wherein each symbol is as defined in the specification. These substances have a remarkable, highly persistent and lowly toxic activity of increasing blood stream in coronary, cerebral, renal and peripheral arteries, and are useful as a potent and persistent hypotensive and a drug for preventing and treating diseases of a cardiovascular system such as coronary, cerebral, renal and peripheral arteries. Furthermore, they are useful as an antasthmatic, because they have activities of inhibiting experimental guinea pig asthma caused by the inhalation of histamine and inhibiting contraction of a specimen of an extirpated guinea pig trachea caused by acetylcholine.