公开(公告)号：EP0641781A4

公开(公告)日：1994-12-16

申请号：EP92918882

申请日：1992-09-04

申请人： YOSHITOMI PHARMACEUTICAL

发明人： ARITA M YOSHITOMI PHARMACEUTIC ,  SAITO T YOSHITOMI PHARMACEUTIC ,  OKUDA H YOSHITOMI PHARMACEUTIC ,  SATO H YOSHITOMI PHARMACEUTICA ,  UEHATA M YOSHITOMI PHARMACEUTI

IPC分类号： C07D213/75 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D471/04 ,  A61K31/415 ,  A61K31/435 ,  A61K31/505 ,  C07D231/38 ,  C07D473/16 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D213/75 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D471/04

摘要： A 4-amino(alkyl)cyclohexane-1-carboxamide compound represented by general formula (I), an isomer thereof, and a pharmaceutically acceptable acid addition salt thereof, wherein each symbol is as defined in the specification. These substances have a remarkable, highly persistent and lowly toxic activity of increasing blood stream in coronary, cerebral, renal and peripheral arteries, and are useful as a potent and persistent hypotensive and a drug for preventing and treating diseases of a cardiovascular system such as coronary, cerebral, renal and peripheral arteries. Furthermore, they are useful as an antasthmatic, because they have activities of inhibiting experimental guinea pig asthma caused by the inhalation of histamine and inhibiting contraction of a specimen of an extirpated guinea pig trachea caused by acetylcholine.