发明公开
EP0651765A1 ANALOGS OF PTH AND PTHRP, THEIR SYNTHESIS AND USE FOR THE TREATMENT OF OSTEOPOROSIS
失效
PTH的PTHrP和模拟生产和使用骨质疏松的治疗。
- 专利标题： ANALOGS OF PTH AND PTHRP, THEIR SYNTHESIS AND USE FOR THE TREATMENT OF OSTEOPOROSIS
- 专利标题（中）： PTH的PTHrP和模拟生产和使用骨质疏松的治疗。
-
申请号： EP93917060.0申请日： 1993-07-13
-
公开(公告)号： EP0651765A1公开(公告)日： 1995-05-10
- 发明人: KRSTENANSKY, John, L. , NESTOR, John, J., Jr. , HO, Teresa, L. , VICKERY, Brian, H. , BACH, Chinh, T.
- 申请人： SYNTEX (U.S.A.) INC.
- 申请人地址： 3401 Hillview Avenue A2-200 Palo Alto, CA 94304 US
- 专利权人： SYNTEX (U.S.A.) INC.
- 当前专利权人： SYNTEX (U.S.A.) INC.
- 当前专利权人地址： 3401 Hillview Avenue A2-200 Palo Alto, CA 94304 US
- 代理机构： Armitage, Ian Michael
- 优先权： US19920915247 19920714
- 国际公布： WO1994001460 19940120
- 主分类号： A61K38
- IPC分类号： A61K38 ; A61K9 ; A61P3 ; A61P19 ; A61P43 ; C07K1 ; C07K14 ; C12N1 ; C12N15 ; A61K47
摘要：
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic α-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of osteoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
信息查询
