专利检索 ap:("SYNTEX (U.S.A.) INC.") AND inv:"VICKERY, Brian, H." 第 1 页

1.

发明授权
ANALOGS OF PTH AND PTHRP, THEIR SYNTHESIS AND USE FOR THE TREATMENT OF OSTEOPOROSIS 失效
标题翻译： PTH的PTHrP和模拟生产和使用骨质疏松的治疗。

公开(公告)号：EP0651765B1

公开(公告)日：2001-06-13

申请号：EP93917060.1

申请日：1993-07-13

申请人： SYNTEX (U.S.A.) INC.

发明人： KRSTENANSKY, John, L. , NESTOR, John, J., Jr. , HO, Teresa, L. , VICKERY, Brian, H. , BACH, Chinh, T.

IPC分类号： C07K14/635 , A61K38/29 , A61P19/10

CPC分类号： A61K9/0043 , A61K38/00 , A61K47/28 , A61K47/40 , C07K14/635 , C07K2319/00

2.

发明公开
METHOD FOR THE TREATMENT OF CORTICOSTEROID INDUCED OSTEOPENIA 失效
标题翻译：方法为糖皮质激素诱导ORTEOPENIE的治疗

公开(公告)号：EP0835262A1

公开(公告)日：1998-04-15

申请号：EP96921256.0

申请日：1996-06-03

申请人： SYNTEX (U.S.A.) INC.

发明人： VICKERY, Brian, H.

IPC分类号： C12N15 , A61K9 , A61K38 , A61P3 , A61P5 , A61P43 , C07K14 , C12N1 , A61K47

CPC分类号： A61K9/0043 , A61K38/00 , A61K47/28 , A61K47/40 , C07K14/635 , C07K2319/00

摘要： Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic α-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of corticosteroid induced osteopenia in mammals.

3.

发明公开
ANALOGS OF PTH AND PTHRP, THEIR SYNTHESIS AND USE FOR THE TREATMENT OF OSTEOPOROSIS 失效
标题翻译： PTH的PTHrP和模拟生产和使用骨质疏松的治疗。

公开(公告)号：EP0651765A1

公开(公告)日：1995-05-10

申请号：EP93917060.0

申请日：1993-07-13

申请人： SYNTEX (U.S.A.) INC.

发明人： KRSTENANSKY, John, L. , NESTOR, John, J., Jr. , HO, Teresa, L. , VICKERY, Brian, H. , BACH, Chinh, T.

IPC分类号： A61K38 , A61K9 , A61P3 , A61P19 , A61P43 , C07K1 , C07K14 , C12N1 , C12N15 , A61K47

CPC分类号： A61K9/0043 , A61K38/00 , A61K47/28 , A61K47/40 , C07K14/635 , C07K2319/00

摘要： Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic α-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of osteoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.