发明公开
EP0672656A1 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof
失效
1,3,4-取代的和2-氮杂环丁酮和它们的制备方法的双环衍生物。
- 专利标题： 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof
- 专利标题（中）： 1,3,4-取代的和2-氮杂环丁酮和它们的制备方法的双环衍生物。
-
申请号： EP95301632.6申请日： 1995-03-13
-
公开(公告)号： EP0672656A1公开(公告)日： 1995-09-20
- 发明人: Aikins, James Abraham , Blaszczak, Larry Chris , Lund, Kevin Patrick , Rizzo, John Robert
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Hudson, Christopher Mark
- 优先权： US213644 19940316
- 主分类号： C07D205/095
- IPC分类号： C07D205/095 ; C07D471/04
摘要：
The invention provides 1,3,4 substituted and bicyclic derivatives of 2-azetidinones of the formula
wherein R is an amino group, a protected amino group, or a group of the formula -NR a R b , wherein R a is an amino protecting group and R b is selected from the group consisting of acryloyl or substituted acryloyl; R¹ is hydrogen or an amide protecting group; R² is a radical forming group; A is -S- or -(SO) n -, wherein n is 0 or 1; and B and C are independently selected from a group consisting of oxygen, sulfur, methylene, selenium, and nitrogen.
These compounds are valuable intermediates useful in the preparation of 1-carba(dethia)cephalosporin antibiotics.
wherein R is an amino group, a protected amino group, or a group of the formula -NR a R b , wherein R a is an amino protecting group and R b is selected from the group consisting of acryloyl or substituted acryloyl; R¹ is hydrogen or an amide protecting group; R² is a radical forming group; A is -S- or -(SO) n -, wherein n is 0 or 1; and B and C are independently selected from a group consisting of oxygen, sulfur, methylene, selenium, and nitrogen.
These compounds are valuable intermediates useful in the preparation of 1-carba(dethia)cephalosporin antibiotics.
信息查询
