发明公开
- 专利标题： INJECTABLE COMPOSITION.
- 专利标题（中）： INJIZIERBARE ZUSAMMENSETZUNG。
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申请号： EP94901593申请日： 1993-11-18
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公开(公告)号： EP0674510A4公开(公告)日： 1995-08-12
- 发明人: CARVER DAVID R , PROUT TIMOTHY R , EWALD HERNITA , ELLIOTT ROBYN , HANDRECK PAUL
- 申请人： NAPRO BIOTHERAPEUTICS INC
- 专利权人： NAPRO BIOTHERAPEUTICS INC
- 当前专利权人： NAPRO BIOTHERAPEUTICS INC
- 优先权： AUPL607492 1992-11-27; US99550192 1992-12-22
- 主分类号： C07D305/14
- IPC分类号： C07D305/14 ; A01D43/02 ; A01N43/02 ; A61J1/00 ; A61K9/00 ; A61K9/08 ; A61K31/335 ; A61K31/337 ; A61K47/02 ; A61K47/10 ; A61K47/12 ; A61K47/14 ; A61K47/44
摘要：
A composition of taxol and polyethoxylated castor oil is pH balanced to have a pH less than 8.1 to improve stability. This composition can include an acid, preferably citric acid, to adjust the pH value. The invention includes a method of formulating a taxol solution for injection by mixing an acid with a carrier material, such as castor oil, to form a carrier solution after which taxol is mixed with the carrier solution to form the taxol solution at a pH of less than 8.1. The method may include the step of slurrying the taxol in alcohol before mixing with the carrier solution.
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