发明公开
EP0678501A1 Process for producing N-chloroacetylglutamine
失效
Verfahren zur Herstellung von N-氯乙酰谷氨酰胺。
- 专利标题： Process for producing N-chloroacetylglutamine
- 专利标题（中）： Verfahren zur Herstellung von N-氯乙酰谷氨酰胺。
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申请号： EP95105656.3申请日： 1995-04-13
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公开(公告)号： EP0678501A1公开(公告)日： 1995-10-25
- 发明人: Amatsu, Kazumi , Yamada, Yoshiyuki , Mori, Yoshikazu , Mizutaki, Shoichi , Kasai, Masaji , Tomioka, Shinji
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo JP
- 代理机构： Riedl, Peter, Dr.
- 优先权： JP78718/94 19940418
- 主分类号： C07C231/10
- IPC分类号： C07C231/10 ; C07C237/22
摘要：
N-chloroacetylglutamine is produced by reacting chloroacetyl chloride with an alkaline aqueous solution of glutamine in the presence of a water-immiscible organic solvent, separating an aqueous layer by liquid-liquid separation, and crystallizing N-chloroacetyl-glutamine from the aqueous layer under acidic conditions. N-Chloroacetylglutamine useful as an intermediate for producing glycyl-L-glutamine which has higher stability than L-glutamine and is used as a component of an infusion solution can be obtained with high efficiency at low cost.
公开/授权文献
- EP0678501B1 Process for producing N-chloroacetylglutamine 公开/授权日：1997-07-30
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