发明公开
EP0685462A1 PROCESS FOR PRODUCING INTERMEDIATE FOR 13,14-DIDEHYDROPROSTAGLANDIN E
失效
生产13,14-二氢前列腺素的中间体的方法E
- 专利标题： PROCESS FOR PRODUCING INTERMEDIATE FOR 13,14-DIDEHYDROPROSTAGLANDIN E
- 专利标题（中）： 生产13,14-二氢前列腺素的中间体的方法E
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申请号： EP94907066.8申请日： 1994-02-17
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公开(公告)号： EP0685462A1公开(公告)日： 1995-12-06
- 发明人: SATO, Fumie
- 申请人： TAISHO PHARMACEUTICAL CO. LTD , Sato, Fumie
- 申请人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 专利权人： TAISHO PHARMACEUTICAL CO. LTD,Sato, Fumie
- 当前专利权人： TAISHO PHARMACEUTICAL CO. LTD,Sato, Fumie
- 当前专利权人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 代理机构： Kraus, Walter, Dr.
- 优先权： JP30199/93 19930219
- 国际公布： WO9419319 19940901
- 主分类号： C07C405/00
- IPC分类号： C07C405/00 ; C07B61/02 ; C07B61/00
摘要：
A process for producing an intermediate for a 13,14-didehydroprostaglandin E, represented by general formula (I), (wherein R⁶ represents -COOR⁹, cyano, hydroxy, -OCOR¹⁰ or -CONR¹¹R¹²; A represents vinylene, ethynylene, phenylene -C=C=C-; X represents oxygen or sulfur; m is 0 to 7; n, q and s are each 0 or 1; and p and r are each 0 to 5) by the free-radical reaction of a compound represented by general formula (II), with a compound represented by the following general formula: Y(CR³R⁴) m A n (CH₂) p X q (CHR⁵) r R⁶, (wherein Y represents halogen or (a)) in the presence of a free-radical generator.
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