发明公开
EP0687675A2 Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
失效
不可逆的HIV蛋白酶抑制剂，Zwischenprodukte，Zusammensetzungen und Verfahren zu ihrer Herstellung
- 专利标题： Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
- 专利标题（中）： 不可逆的HIV蛋白酶抑制剂，Zwischenprodukte，Zusammensetzungen und Verfahren zu ihrer Herstellung
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申请号： EP95108908.5申请日： 1995-06-09
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公开(公告)号： EP0687675A2公开(公告)日： 1995-12-20
- 发明人: Yoon, Heungsik , Choy, Nakyen , Kim, Sung Chun , Choi, Ho II , Son, Young Chan , Park, Chi Hyo , Moon, Kwang-Yul , Jung, Wonhee , Kim, Chung Ryeol , Lee, Chang Sun , Koh, Jong Sung , Kim, Sang Soo
- 申请人： LG Chemical Limited
- 申请人地址： 20, Yoido-dong, Yongdungpo-gu Seoul 150-721 KR
- 专利权人： LG Chemical Limited
- 当前专利权人： LG Chemical Limited
- 当前专利权人地址： 20, Yoido-dong, Yongdungpo-gu Seoul 150-721 KR
- 代理机构： Turi, Michael, Dipl.-Phys.
- 优先权： KR9413423 19940615
- 主分类号： C07D303/36
- IPC分类号： C07D303/36 ; C07D303/40 ; C07D405/12 ; C07D407/12 ; A61K31/335 ; A61K31/435 ; C07C271/22 ; C07C233/87 ; C07C229/34
摘要：
Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection:
wherein A, B, R 1 to R 4 and n have the same meanings as defined in the specification.
The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.
wherein A, B, R 1 to R 4 and n have the same meanings as defined in the specification.
The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.
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