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1.发明公开Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof 失效不可逆的HIV蛋白酶抑制剂，中间体，组合物和它们的制备方法
公开(公告)号：EP0687675A3
公开(公告)日：1996-03-06
申请号：EP95108908.5
申请日：1995-06-09
申请人： LG Chemical Limited
发明人： Yoon, Heungsik , Choy, Nakyen , Kim, Sung Chun , Choi, Ho II , Son, Young Chan , Park, Chi Hyo , Moon, Kwang-Yul , Jung, Wonhee , Kim, Chung Ryeol , Lee, Chang Sun , Koh, Jong Sung , Kim, Sang Soo
IPC分类号： C07D303/36 , C07D303/40 , C07D405/12 , C07D407/12 , A61K31/335 , A61K31/435 , C07C271/22 , C07C233/87 , C07C229/34
CPC分类号： C07D405/12 , C07C271/22 , C07C273/1836 , C07D303/46 , C07D407/12 , C07D409/12 , C07K5/0207
摘要： Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection:
wherein A, B, R 1 to R 4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.-
2.发明公开Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof 失效不可逆的HIV蛋白酶抑制剂，Zwischenprodukte，Zusammensetzungen und Verfahren zu ihrer Herstellung
公开(公告)号：EP0687675A2
公开(公告)日：1995-12-20
申请号：EP95108908.5
申请日：1995-06-09
申请人： LG Chemical Limited
发明人： Yoon, Heungsik , Choy, Nakyen , Kim, Sung Chun , Choi, Ho II , Son, Young Chan , Park, Chi Hyo , Moon, Kwang-Yul , Jung, Wonhee , Kim, Chung Ryeol , Lee, Chang Sun , Koh, Jong Sung , Kim, Sang Soo
IPC分类号： C07D303/36 , C07D303/40 , C07D405/12 , C07D407/12 , A61K31/335 , A61K31/435 , C07C271/22 , C07C233/87 , C07C229/34
CPC分类号： C07D405/12 , C07C271/22 , C07C273/1836 , C07D303/46 , C07D407/12 , C07D409/12 , C07K5/0207
摘要： Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection:
wherein A, B, R 1 to R 4 and n have the same meanings as defined in the specification.
The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.摘要翻译： 式（I）的新型顺式环氧化合物可用于治疗或预防由HIV感染引起的疾病：
其中A，B，R 1至R 4和n具有与说明书中所定义的相同的含义。 式（I）的新型HIV蛋白酶抑制剂具有与酶活性位点形成稳定结合的特定结构，这需要高度增强的对HIV蛋白酶的不可逆抑制。
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