发明公开
EP0690127A1 Compositions and methods for stimulating megakaryocyte growth and differentiation
失效
组合物和方法用于刺激巨核细胞的生长和分化
- 专利标题： Compositions and methods for stimulating megakaryocyte growth and differentiation
- 专利标题（中）： 组合物和方法用于刺激巨核细胞的生长和分化
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申请号： EP95104745.5申请日： 1995-03-30
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公开(公告)号： EP0690127A1公开(公告)日： 1996-01-03
- 发明人: Bartley, Timothy D. , Bogenberger, Jakob M. , Bosselman, Robert A. , Hunt, Pamela , Samal, Babru B. , Kinstler, Olaf B.
- 申请人： AMGEN INC.
- 申请人地址： Amgen Center, 1840 Dehavilland Drive Thousand Oaks, CA 91320-1789 US
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： Amgen Center, 1840 Dehavilland Drive Thousand Oaks, CA 91320-1789 US
- 代理机构： Brown, John David
- 优先权： US221768 19940331; US252628 19940531; US321488 19941012; US347780 19941130
- 主分类号： C12N15/19
- IPC分类号： C12N15/19 ; C07K14/52 ; C07K17/08 ; A61K38/19 ; A61K47/48
摘要：
Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
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