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    Compositions and methods for stimulating megakaryocyte growth and differentiation
    3.
    发明公开
    Compositions and methods for stimulating megakaryocyte growth and differentiation 失效
    组合物和用于刺激巨核细胞的生长和分化的方法。

    公开(公告)号：EP0675201A1

    公开(公告)日：1995-10-04

    申请号：EP95104711.7

    申请日：1995-03-30

    申请人： AMGEN INC.

    发明人： Bartley, Timothy D. ,  Bogenberger, Jakob M. ,  Bosselman, Robert A. ,  Hunt, Pamela ,  Samal, Babru B. ,  Kinstler, Olaf B.

    IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N5/10 ,  C07K16/24 ,  A61K38/19 ,  C07K17/08 ,  A61K47/48

    CPC分类号： C07K17/08 ,  A61K38/00 ,  A61K47/60 ,  C07K14/524 ,  Y10S930/14

    摘要： Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.

    摘要翻译： 本发明公开了新的蛋白质，通过向称为巨核细胞生长和发育因子（MGDFs，所以基因反弹由被称为的Mpl配体），确实有刺激巨核细胞的生长，以及增加巨核细胞的分化或成熟的生物活性，最终导致 血小板生成。 MGDF衍生物包括附接到水溶性聚合物，聚乙二醇分子MGDF：如，被游离缺失盘，地连同它们的制备方法。 所以光盘游离缺失是从天然来源同质的形式获得的MGDFs和由哺乳动物重组基因工程技术，包括人类生产它们的过程。

    Stem cell factor
    4.
    发明授权
    Stem cell factor 失效
    干细胞因子

    公开(公告)号：EP0423980B1

    公开(公告)日：2000-07-12

    申请号：EP90310899.1

    申请日：1990-10-04

    申请人： AMGEN INC.

    发明人： Zsebo, Krisztina M. ,  Suggs, Sidney Vaughn ,  Bosselman, Robert A. ,  Martin, Francis Hall

    IPC分类号： C12N15/12 ,  C12P21/02 ,  C07K14/475 ,  C12N1/21

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K16/22 ,  Y02A50/409 ,  Y02A50/411 ,  Y10S530/81

    摘要： Non-naturally occurring polypeptide (I) is claimed, whose aminoacid sequence is similar enough to naturally-occurring stem cell factor (SCF) to give it the same haematopoietic biological activity. (I) is produced by eukaryotic or prokaryotic expression of an exogeneous DNA sequence, and has in vivo and in vitro biological activity. Also claimed are a DNA sequence encoding (I), a host transformed with the DNA sequence, a process for producing and recoverng SCF, a DNA sequence encoding a human SCF analogue, an antibody that binds SCF, a compsn.; of (I) with a water-soluble polymer, a method of preparing the above compsn. and a method of transfecting early haematopoietic stem cells. Routes of administration are e.g. parenteral, pulmonary, nasal and oral.

    Compositions and methods for stimulating megakaryocyte growth and differentiation
    5.
    发明公开
    Compositions and methods for stimulating megakaryocyte growth and differentiation 失效
    组合物和方法用于刺激巨核细胞的生长和分化

    公开(公告)号：EP0690127A1

    公开(公告)日：1996-01-03

    申请号：EP95104745.5

    申请日：1995-03-30

    申请人： AMGEN INC.

    发明人： Bartley, Timothy D. ,  Bogenberger, Jakob M. ,  Bosselman, Robert A. ,  Hunt, Pamela ,  Samal, Babru B. ,  Kinstler, Olaf B.

    IPC分类号： C12N15/19 ,  C07K14/52 ,  C07K17/08 ,  A61K38/19 ,  A61K47/48

    CPC分类号： C07K17/08 ,  A61K38/00 ,  A61K47/60 ,  C07K14/524 ,  Y10S930/14

    摘要： Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.

    摘要翻译： 本发明公开了新的蛋白质，通过向称为巨核细胞生长和发育因子（MGDFs，所以基因反弹由被称为的Mpl配体），确实有刺激巨核细胞的生长，以及增加巨核细胞的分化或成熟的生物活性，最终导致 血小板生成。 MGDF衍生物包括附接到水溶性聚合物，聚乙二醇分子MGDF：如，被游离缺失盘，地连同它们的制备方法。 所以光盘游离缺失是从天然来源同质的形式获得的MGDFs和由哺乳动物重组基因工程技术，包括人类生产它们的过程。