发明公开
- 专利标题： PRODUCTION OF RECOMBINANT FACTOR XA INHIBITOR OF LEECH HIRUDO MEDICINALIS
- 专利标题（中）： 生产水蛭重组Xa因子抑制剂
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申请号： EP94914102.0申请日： 1994-04-08
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公开(公告)号： EP0693925A1公开(公告)日： 1996-01-31
- 发明人: WERBER, Moshe M. , ZEELON, Elisha P. , LEVANON, Avigdor , GUY, Rachel , GOLDLUST, Arie , RIGBI, Meir , PANET, Amos , FISCHER, Meir
- 申请人： BIO-TECHNOLOGY GENERAL CORP. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
- 申请人地址： 70 Wood Avenue South Iselin, NJ 08830 US
- 专利权人： BIO-TECHNOLOGY GENERAL CORP.,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
- 当前专利权人： BIO-TECHNOLOGY GENERAL CORP.,YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
- 当前专利权人地址： 70 Wood Avenue South Iselin, NJ 08830 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US19930045804 19930409
- 国际公布： WO1994023709 19941027
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K38 ; A61P7 ; A61P31 ; A61P43 ; C07K1 ; C07K14 ; C07K16 ; C12N1 ; C12N9 ; C12P21 ; C12R1
摘要：
The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr?26 - gly110¿ where tyr?26 - gly110¿ is identical to the sequence shown in Figure 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
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