发明授权
EP0714400B1 THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4"-DEOXY-4"-(EPI)-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION
失效
THERMO型动态4“ - 脱氧-4”甲胺基阿维菌素阿维菌素BIA / BIB BENZOESAURESALZ稳定晶形及其制造方法
- 专利标题： THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4"-DEOXY-4"-(EPI)-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION
- 专利标题（中）： THERMO型动态4“ - 脱氧-4”甲胺基阿维菌素阿维菌素BIA / BIB BENZOESAURESALZ稳定晶形及其制造方法
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申请号： EP94926502.9申请日： 1994-08-15
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公开(公告)号： EP0714400B1公开(公告)日： 1999-12-15
- 发明人: CVETOVICH, Raymond , DEMCHAK, Richard , McCAULEY, James, A. , VARSALONA, Richard, J.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Hiscock, Ian James
- 优先权： US109189 19930819
- 国际公布： WO9505390 19950223
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; A01N43/90
摘要：
The most thermodynamically stable crystalline form of the benzoic acid salt of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
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