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    APPARATUS FOR INJECTING A PHARMACEUTICAL
    5.
    发明公开
    APPARATUS FOR INJECTING A PHARMACEUTICAL 审中-公开
    DEVICE注射用的药物MEANS

    公开(公告)号：EP1948269A1

    公开(公告)日：2008-07-30

    申请号：EP06825646.0

    申请日：2006-10-10

    申请人： ELI LILLY AND COMPANY

    发明人： JAMES, Adrian Benton ,  LISTER, Robert Ian ,  MACDONALD, Peter Scott

    IPC分类号： A61M5/20 ,  A61M5/42 ,  A61M5/32

    CPC分类号： A61M5/3287 ,  A61M5/3134 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3243 ,  A61M5/42 ,  A61M2005/3215 ,  A61M2005/3247

    摘要： A pharmaceutical delivery apparatus including a housing (22) , a syringe assembly, and a needle (44) cap. The syringe assembly is plungeable relative to the housing from a first position, at which its needle tip is disposed within the housing, to a second position, at which its needle tip projects from the housing beyond the proximal end for insertion into an injection site. A base (46) of the needle cap is exposed at the housing proximal end to be manually grippable for cap removal. A needle cap stem is upstanding from the base and sized and configured to insert through an opening is the housing proximal end to cover the needle tip when the syringe assembly is disposed in the first position. The needle cap base further includes a plurality of distally projecting cams (54, 258) located radially outward of the stem. The cams are fittable within slots (40, 240) in the housing proximal end when the cap is fully mounted to the apparatus.

    Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat non-insulin dependent diabetes
    7.
    发明公开
    Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat non-insulin dependent diabetes 审中-公开
    协同使用噻唑烷二酮与胰高血糖素样肽-1及其激动剂用于非胰岛素依赖性糖尿病的治疗

    公开(公告)号：EP1849475A1

    公开(公告)日：2007-10-31

    申请号：EP07111988.7

    申请日：2000-06-06

    申请人： Eli Lilly & Company

    发明人： Yakubu-Madus, Fatima Emitsel ,  Stramm, Lawrence E ,  Johnson, William T ,  Vignati, Louis

    IPC分类号： A61K38/22 ,  A61K38/26 ,  A61P3/08 ,  A61K31/425

    CPC分类号： A61K31/425 ,  A61K38/26 ,  A61K2300/00

    摘要： Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects, such as heart hypertrophy and elevated fed-state plasma glucose, which are associated with both TZD and GLP-1 monotherapies. Thus, the co-administration of TZD and GLP-1 helps regulate glucose homeostasis in Type II diabetic patients.

    摘要翻译： 噻唑烷二酮（TZD）及其药理学上的活性衍生物，可以使用结合的同时最小化胰高血糖素样肽-1（GLP-1），治疗非胰岛素依赖型糖尿病，任选与其他治疗，通过改善血糖控制激动剂 副作用，：如心脏肥大和升高的进食状态下的血浆葡萄糖，其与TZD和GLP-1两种单一疗法相关的。 因此，TZD和GLP-1的共同给予帮助调节II型糖尿病患者的血糖稳态。