发明公开
- 专利标题： PROCESS FOR GENERATING SPECIFIC ANTIBODIES
- 专利标题（中）： 产生特异性抗体的过程
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申请号： EP95905871.0申请日： 1994-12-08
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公开(公告)号： EP0733070A1公开(公告)日： 1996-09-25
- 发明人: BARSOMIAN, Gary , COPELAND, Diane, P. , HILLHOUSE, Dana , JOHNSON, Tracy
- 申请人： GENZYME CORPORATION
- 申请人地址： One Mountain Road Framingham, Massachusetts 01701 US
- 专利权人： GENZYME CORPORATION
- 当前专利权人： GENZYME CORPORATION
- 当前专利权人地址： One Mountain Road Framingham, Massachusetts 01701 US
- 代理机构： Froud, Clive, et al
- 优先权： US19930164022 19931208; US19940350400 19941206
- 国际公布： WO1995015982 19950615
- 主分类号： G01N33
- IPC分类号： G01N33 ; C07K16 ; C12N1 ; C12N15 ; C12P21 ; C12R1
摘要：
The present invention relates to a method for generating an antibody which is specific for an immunorecessive epitope, and nucleic acid encoding the antibody. The subject method generally comprises the steps of generating a variegated display library of antibody variable regions, and selecting from the library those antibody variable regions which have a desired binding specificity for the immunorecessive epitope. The antibody variable regions used to generate the display library are cloned from an immunotolerance-derived antibody repertoire.
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