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公开(公告)号：EP3765846B1
公开(公告)日：2024-10-30
申请号：EP19714056.9
申请日：2019-03-15
发明人： WANG, Jonathan , SHAH, Neha , WALTHER, Jason , LU, Jiuyi , JOHNSON, Timothy , REN, Yukun , MCLARTY, Jean
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公开(公告)号：EP3280799B1
公开(公告)日：2024-10-30
申请号：EP16767050.4
申请日：2016-04-07
IPC分类号： C12N7/00 , C12N15/864 , C12N5/10 , A61K48/00
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公开(公告)号：EP4163299B1
公开(公告)日：2024-10-02
申请号：EP22180865.2
申请日：2016-03-03
IPC分类号： C07K16/22
CPC分类号： C07K2317/2120130101 , C07K2317/5220130101 , C07K2317/52220130101 , C07K2317/5320130101 , C07K2317/5520130101 , C07K2317/56720130101 , C07K2317/62220130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2317/9420130101 , C07K16/22 , A61P13/12 , A61P17/00 , A61P19/08 , A61P35/00 , A61P37/00 , A61P37/02
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公开(公告)号：EP4345165A3
公开(公告)日：2024-09-25
申请号：EP23176679.1
申请日：2015-03-20
申请人： Genzyme Corporation
IPC分类号： A61K48/00 , A61K31/7105 , C12N15/86
CPC分类号： A61K31/7105 , C12N15/86 , C12N2310/14120130101 , C12N2750/1414320130101 , A61K9/0019 , A61K9/0048 , C12N15/113 , C12N2320/3420130101 , C12N2330/5120130101 , A61K38/1709 , A61P27/02 , A61P43/00 , C12N2830/4220130101
摘要： Provided herein are methods for treating retinitis pigmentosa using an AAV particles encoding miR-708. In one aspect, viral particles are administered to the eye of a human subject; for example, by subretinal injection. Viral particles comprising AAV5 capsids or mutants thereof are contemplated.
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公开(公告)号：EP4424828A1
公开(公告)日：2024-09-04
申请号：EP24157647.9
申请日：2016-12-07
申请人： Genzyme Corporation
发明人： Akinc, Akin , Sorensen, Benny , Garg, Pushkal , Robbie, Gabriel
IPC分类号： C12N15/113 , A61K31/713 , A61P7/04
CPC分类号： C12N2320/3520130101 , A61K47/549 , A61K31/713 , C12N15/113 , C12N2310/1420130101 , C12N2310/31520130101 , C12N2310/34620130101 , C12N2310/35120130101 , A61P43/00 , A61P7/04
摘要： The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.
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公开(公告)号：EP4396176A1
公开(公告)日：2024-07-10
申请号：EP22777554.1
申请日：2022-09-02
申请人： GENZYME CORPORATION
发明人： LIAO, Junkai , MUNSON, Mark , THURAIRATNAM, Sukanthini , HIRTH, Bradford , GAO, Zhongli , HURLBUT, Gregory , BORCHERDING, David , BARRAGUE, Matthieu , GILLESPY, Timothy, Alan , GROSS, Alexandre , NIEDUZAK, Thaddeus , GOOD, Andrew , VAZ, Roy , LIU, Jinyu , LI, Yi , METZ, Markus , RUVINSKY, Anatoly , KOTHE, Michael
IPC分类号： C07D401/14 , C07D403/10 , C07D403/12 , C07D413/12 , C07D417/14 , C07D471/04 , A61P11/00 , A61K31/404
CPC分类号： C07D417/14 , C07D403/12 , C07D471/04 , C07D401/14 , C07D403/10 , C07D413/12 , A61P11/00
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公开(公告)号：EP4355363A1
公开(公告)日：2024-04-24
申请号：EP22744862.8
申请日：2022-06-17
申请人： GENZYME CORPORATION
CPC分类号： A61K2039/55520130101 , A61K39/39591 , C07K16/22 , A61K9/0019 , A61K47/26 , A61K47/12 , A61K9/08 , A61K47/183
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公开(公告)号：EP3094392B1
公开(公告)日：2024-04-24
申请号：EP15702074.4
申请日：2015-01-16
IPC分类号： B01D15/20 , B01D15/36 , B01D15/18 , B01D15/34 , B01D15/38 , B01J20/281 , A61L2/08 , B01J20/26 , B01J39/26 , B01J41/12 , B01J41/20 , B01D15/32 , B01J20/34
CPC分类号： B01D15/1864 , B01D15/20 , B01D15/327 , B01D15/34 , B01D15/362 , B01J39/26 , Y10T29/49826 , B01D15/363 , B01D15/3804 , B01J20/265 , B01J20/281 , B01J20/3441 , B01J41/12 , B01J41/20 , A61L2/081
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公开(公告)号：EP4353723A1
公开(公告)日：2024-04-17
申请号：EP22819443.7
申请日：2022-06-02
申请人： GENZYME CORPORATION
发明人： CHEN, Minhua , SHI, Jiaming , ZHANG, Jing
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P37/00 , A61P25/00 , A61P37/06
CPC分类号： A61K31/437 , A61K31/4545 , A61P25/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07D471/04
摘要： The present invention relates to a new crystal form of tolebrutinib (hereinafter referred to as "compound I"), a preparation method therefor, a pharmaceutical composition containing the crystal form, and the use of same in the preparation of a BTK inhibitor drug and a drug for treating multiple sclerosis. The crystal form of tolebrutinib provided has one or more improved properties compared with the prior art, and is of great value to the optimization and development of drugs in the future.
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公开(公告)号：EP3628334B1
公开(公告)日：2023-06-28
申请号：EP19186929.6
申请日：2015-03-20
IPC分类号： A61K48/00 , A61K31/7105 , C12N15/86
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