发明公开
- 专利标题： METHOD FOR INDUCING DNA SYNTHESIS IN NEURONS
- 专利标题（中）： 法DNA合成的诱导神经元
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申请号： EP95907228.0申请日： 1994-12-19
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公开(公告)号： EP0734438A1公开(公告)日： 1996-10-02
- 发明人: NORNES, Howard O. , NEUMAN, Toomas , SUDA, Kikuo
- 申请人： SPINAL CORD SOCIETY
- 申请人地址： Route 5, Box 225, Wendell Road Fergus Falls, Minnesota 56537 US
- 专利权人： SPINAL CORD SOCIETY
- 当前专利权人： SPINAL CORD SOCIETY
- 当前专利权人地址： Route 5, Box 225, Wendell Road Fergus Falls, Minnesota 56537 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US19930169522 19931217; US19940301416 19940908
- 国际公布： WO1995016774 19950622
- 主分类号： C07K14
- IPC分类号： C07K14 ; C12N9 ; C12N15
摘要：
A method is provided for inducing DNA synthesis in a differentiated neuron, which includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.
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