公开(公告)号：EP0734438A4

公开(公告)日：1998-12-23

申请号：EP95907228

申请日：1994-12-19

申请人： SPINAL CORD SOCIETY

发明人： NORNES HOWARD O ,  NEUMAN TOOMAS ,  SUDA KIKUO

IPC分类号： C07K14/075 ,  C07K14/47 ,  C07K14/48 ,  C12N9/02 ,  C12N15/85 ,  C12N15/10 ,  C12N15/64

CPC分类号： C07K14/005 ,  C07K14/4738 ,  C07K14/48 ,  C12N9/0071 ,  C12N15/85 ,  C12N2710/10322 ,  C12Y114/13041 ,  C12Y114/16002

摘要： A method is provided for inducing DNA synthesis in a differentiated neuron, which includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

公开(公告)号：EP0734438A1

公开(公告)日：1996-10-02

申请号：EP95907228.0

申请日：1994-12-19

申请人： SPINAL CORD SOCIETY

发明人： NORNES, Howard O. ,  NEUMAN, Toomas ,  SUDA, Kikuo

IPC分类号： C07K14 ,  C12N9 ,  C12N15

CPC分类号： C07K14/005 ,  C07K14/4738 ,  C07K14/48 ,  C12N9/0071 ,  C12N15/85 ,  C12N2710/10322 ,  C12Y114/13041 ,  C12Y114/16002

摘要： A method is provided for inducing DNA synthesis in a differentiated neuron, which includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a differentiated neuron, and transfecting a differentiated neuron with the vector. According to certain embodiments of the invention, a method for integrating DNA encoding a desired protein in a differentiated neuron is provided that includes obtaining a vector comprising nucleic acid encoding an E2F regulator and/or an E1A regulator, wherein the vector can be used to express the nucleic acid in a neuron, obtaining DNA encoding a desired protein, and cotransfecting a differentiated neuron with the vector and the DNA encoding the desired protein such that the DNA encoding the desired protein is integrated in the differentiated neuron and the desired protein is produced.

公开(公告)号：EP0619123A3

公开(公告)日：1997-08-06

申请号：EP94400761.6

申请日：1994-04-07

申请人： SPINAL CORD SOCIETY

发明人： Jeutter, Dean C. ,  Geisler, Mark S.

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/372 ,  Y10S128/903

摘要： A regenerative electrical stimulation device (20) comprising a stimulator portion to be surgically implanted in patients and an external controller portion. The implanted stimulator portion provides electrical stimuli of selected parameters to damaged nerve tissue to stimulate regeneration and/or healing of the damaged nerve tissue. The external controller portion communicates with the implanted stimulator portion to turn the stimulator portion on and off, to change the parameters of the electrical stimuli, to recharge the batteries, and to monitor the status of the batteries. The implanted portion has an antenna coil (32), a receiver (24), a programmable control processor (90), rechargeable batteries (28), and a passive transmitter. The external controller portion (22) has an antenna coil (30), a control processor (50), a transmitter, a receiver for receiving the data passively transmitted by the implantable portion, and a display means.

公开(公告)号：EP0619123A2

公开(公告)日：1994-10-12

申请号：EP94400761.6

申请日：1994-04-07

申请人： SPINAL CORD SOCIETY

发明人： Jeutter, Dean C. ,  Geisler, Mark S.

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/372 ,  Y10S128/903

摘要： A regenerative electrical stimulation device (20) comprising a stimulator portion to be surgically implanted in patients and an external controller portion. The implanted stimulator portion provides electrical stimuli of selected parameters to damaged nerve tissue to stimulate regeneration and/or healing of the damaged nerve tissue. The external controller portion communicates with the implanted stimulator portion to turn the stimulator portion on and off, to change the parameters of the electrical stimuli, to recharge the batteries, and to monitor the status of the batteries. The implanted portion has an antenna coil (32), a receiver (24), a programmable control processor (90), rechargeable batteries (28), and a passive transmitter. The external controller portion (22) has an antenna coil (30), a control processor (50), a transmitter, a receiver for receiving the data passively transmitted by the implantable portion, and a display means.

摘要翻译： 再生电刺激装置包括要手术植入患者的刺激器和外部控制器。 植入的刺激器为受损的神经组织提供所选参数的电刺激，以刺激受损的神经组织的再生和/或愈合。 外部控制器与植入的刺激器部分通信以打开和关闭刺激器，以改变电刺激的参数，对电池进行再充电并监视电池的状态。 植入部分具有天线线圈，接收器，可编程控制处理器，可充电电池和无源发射器。 外部控制器具有天线线圈，控制处理器，发射器，用于接收被可植入部分被动地发送的数据的接收器和显示器。