发明公开
EP0772634A1 MONOCLONAL ANTIBODIES SPECIFIC FOR AN EPITOPE OF A PARTICULAR SUBCLASS OR FORM OF PHOSPHORYLATED TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION OF THESE ANTIBODIES AND THEIR APPLICATIONS
失效
针对表位某师或磷酸化tau蛋白的单克隆抗体，杂交瘤THESE塞泽尔肾，抗原识别这些抗体及其用途
- 专利标题： MONOCLONAL ANTIBODIES SPECIFIC FOR AN EPITOPE OF A PARTICULAR SUBCLASS OR FORM OF PHOSPHORYLATED TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION OF THESE ANTIBODIES AND THEIR APPLICATIONS
- 专利标题（中）： 针对表位某师或磷酸化tau蛋白的单克隆抗体，杂交瘤THESE塞泽尔肾，抗原识别这些抗体及其用途
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申请号： EP95928494.0申请日： 1995-07-31
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公开(公告)号： EP0772634A1公开(公告)日： 1997-05-14
- 发明人: VANMECHELEN, Eugeen , VAN DE VOORDE, Andre
- 申请人： INNOGENETICS N.V.
- 申请人地址： Industriepark Zwijnaarde 7, Box 4 B-9052 Zwijnaarde BE
- 专利权人： INNOGENETICS N.V.
- 当前专利权人： INNOGENETICS N.V.
- 当前专利权人地址： Industriepark Zwijnaarde 7, Box 4 B-9052 Zwijnaarde BE
- 代理机构： De Clercq, Ann
- 优先权： EP19940870131 19940729
- 国际公布： WO1996004309 19960215
- 主分类号： C12N15
- IPC分类号： C12N15 ; C07K14 ; C07K16 ; C12N5 ; C12N9 ; C12P21 ; G01N33
摘要：
The present invention relates to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of a particular subclass or form of phosphorylated tau protein without forming an immunological complex with (i) fetal tau or (ii) biopsy or autopsy derived brain material from patients having died or suffering from diseases in which NFT is not a pathological hallmark. The invention also relates to a process for diagnosing brain diseases involving monoclonal antibodies of the invention. The invention also relates to a region of the tau molecule which is specifically recognized by the monoclonal antibodies of the invention. The invention also relates to kinases or phosphorylases which specifically react with the epitope recognized by these monoclonal antibodies as well as to a method for screening compounds which interfere with the activity of these kinases and phosphorylases.
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