公开(公告)号：EP2205633A1

公开(公告)日：2010-07-14

申请号：EP08844119.1

申请日：2008-10-24

申请人： Innogenetics N.V. ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Sanofi-Aventis ,  Innogenetics N.V.

发明人： VANMECHELEN, Eugeen ,  GROGNET, Pierre ,  SERGEANT, Nicolas ,  GOMPEL, Marie ,  DELACOURTE, André ,  BUEE, Luc ,  PRADIER, Laurent ,  BLANCHARD-BREGEON, Véronique

IPC分类号： C07K16/18 ,  A61K39/395 ,  G01N33/577 ,  C12N5/18 ,  C07K14/47 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/4711 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

摘要： The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of Aβ8-X peptide, x being comprised from 11 to 42, and recognises neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-X peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-X.

公开(公告)号：EP2314715B1

公开(公告)日：2013-08-14

申请号：EP10008785.7

申请日：2000-04-05

申请人： Innogenetics N.V.

发明人： De Canck, Ilse ,  Rombout, Annelies ,  Rossau, Rudi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q2600/172

公开(公告)号：EP0992581B2

公开(公告)日：2011-05-25

申请号：EP99116672.9

申请日：1994-10-28

申请人： Innogenetics N.V.

发明人： Leroux-Roels, Geert ,  Deleys, Robert ,  Maertens, Geert

IPC分类号： C12N15/09 ,  C07K14/18 ,  C12N15/40 ,  A61K39/12 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2770/24222 ,  C12N2770/36022 ,  Y10S530/806 ,  Y10S530/826

公开(公告)号：EP2322669A2

公开(公告)日：2011-05-18

申请号：EP10181900.1

申请日：1997-04-21

申请人： Innogenetics N.V.

发明人： Maertens, Geert ,  Rossau, Rudi ,  Stuyver, Lieven

IPC分类号： C12Q1/70

CPC分类号： C12Q1/706

摘要： The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT pol gene region and/or to a mutant target sequence chosen from the HBV preCore region and/or to a mutant target sequence chosen from the HBsAg region of HBV and/or to a HBV genotype-specific target sequence, with said target sequences being chosen from Figure 1 , and with said probes being applied to known locations on a solid support and with said probes being capable of hybridizing to the polynucleic acids of the sample under the same hybridization and wash conditions, or with said probes hybridizing specifically with a sequence complementary to any of said target sequences, or a sequence wherein T of said target sequence is replaced by U; and detecting the hybrids formed; and inferring the HBV genotype and/or mutants present in said sample from the differential hybridization signal(s) obtained.
The invention further relates to sets of nucleotide probes and possibly primers useful in said methods as well as to their use in a method for typing and/orp detecting HBV and to assay kits using the same.

公开(公告)号：EP1931801A2

公开(公告)日：2008-06-18

申请号：EP06806736.2

申请日：2006-08-30

申请人： Innogenetics N.V.

发明人： NUYTINCK, Lieve

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to a method and kit for identifying a subject at risk of, or having, an indication associated with altered innate immunity. The present invention is based on the determination of Toll Like Receptor (TLR) genotypes and/or serum levels.

公开(公告)号：EP1911765A3

公开(公告)日：2008-04-23

申请号：EP07124051.9

申请日：2003-07-18

申请人： Innogenetics N.V.

发明人： Delacourte, André ,  Sergeant, Nicolas

IPC分类号： C07K14/47 ,  A61K39/00 ,  C07K16/44 ,  G01N33/50

CPC分类号： A61K39/0007 ,  C07K14/4711 ,  C07K16/18 ,  G01N33/6896 ,  G01N2800/2821

摘要： The invention provides compositions and methods for prevention and treatment of diseases associated with β-amyloid formation and/or aggregation. Such methods encompass the induction of an immune response against N-terminal truncated and/or post-translationally modified Aβ peptides. These peptides are further used in compositions and methods for the diagnosis of diseases associated with β-amyloid formation and/or aggregation.

公开(公告)号：EP0891982B1

公开(公告)日：2007-06-13

申请号：EP98202777.3

申请日：1993-03-08

申请人： Innogenetics N.V.

发明人： De Leys, Robert J.

IPC分类号： C07K1/13 ,  G01N33/531 ,  G01N33/569 ,  C07K14/16 ,  C07K14/18

CPC分类号： C07K1/13 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/14022 ,  C12N2740/16122 ,  C12N2770/24222 ,  G01N33/531 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6878 ,  G01N2333/18

公开(公告)号：EP0944649B1

公开(公告)日：2006-10-18

申请号：EP98947487.9

申请日：1998-08-31

申请人： Innogenetics N.V.

发明人： MEHEUS, Lydie ,  LÜHRMANN, Reinhard, Georg ,  UNION, Ann ,  RAYMACKERS, Joseph

IPC分类号： C07K14/705 ,  C07K16/18 ,  C07K16/42 ,  G01N33/564 ,  C12N15/12 ,  C12P21/02 ,  A61K38/17

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/001 ,  C07K14/4713 ,  C07K14/525 ,  C07K2319/00

摘要： The present invention relates to a method of producing certain peptides containing methylated arginines that are followed by a glycine residue and that constitute immunogenic determinants of antibodies present in sera from patients with systemic lupus erythematosus, or Epstein-Barr virus and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptides for diagnosis and treatment of systemic lupus erythematosus and related diseases, and diseases in which Epstein-Barr virus has been implicated.

公开(公告)号：EP1250600B1

公开(公告)日：2006-10-11

申请号：EP01909655.1

申请日：2001-01-18

申请人： Innogenetics N.V.

发明人： VANMECHELEN, Eugeen ,  VANDERSTICHELE, Hugo

IPC分类号： G01N33/68 ,  A61K38/17 ,  C07K14/47

CPC分类号： C07K14/4711 ,  A61K38/00 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/52 ,  Y10S435/975 ,  Y10T436/10

摘要： The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/ total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.

公开(公告)号：EP1064309B1

公开(公告)日：2006-08-16

申请号：EP99917909.6

申请日：1999-03-29

申请人： Innogenetics N.V.

发明人： MAERTENS, Geert ,  DEPLA, Erik ,  BUYSE, Marie-Ange

IPC分类号： C07K16/10 ,  C12N5/20 ,  G01N33/576 ,  C07K14/18

CPC分类号： C07K14/005 ,  C07K16/109 ,  C12N2770/24222

摘要： Antibodies to two new epitopes on the HCV envelope proteins were identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper variable region of E2 aa 395-415. Surprisingly, we characterised an antibody that reacts with various sequences of the hypervariable domain of E2. Specific monoclonal antibodies directed against these epitopes and allowing routine detection of viral antigen are described.