发明公开
EP0782453A1 COMPOSITIONS CONTAINING TUMOR REJECTION ANTIGEN PRECURSORS OR TUMOR REJECTION ANTIGENS, AND AN ADJUVANT AND/OR GROWTH FACTOR
失效
组合物，其肿瘤抗原不一致PRE-或肿瘤抗原可恶包含佐剂和/或生长因子的
- 专利标题： COMPOSITIONS CONTAINING TUMOR REJECTION ANTIGEN PRECURSORS OR TUMOR REJECTION ANTIGENS, AND AN ADJUVANT AND/OR GROWTH FACTOR
- 专利标题（中）： 组合物，其肿瘤抗原不一致PRE-或肿瘤抗原可恶包含佐剂和/或生长因子的
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申请号： EP95938112.0申请日： 1995-09-27
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公开(公告)号： EP0782453A1公开(公告)日： 1997-07-09
- 发明人: VAN DER BRUGGEN, Pierre , BOON-FALLEUR, Thierry , VAN DEN EYNDE, Benoit
- 申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 申请人地址： 1345 Avenue of the Americas New York, New York 10105 US
- 专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人地址： 1345 Avenue of the Americas New York, New York 10105 US
- 代理机构： Fyles, Julie Marie, et al
- 优先权： US19940315961 19940930
- 国际公布： WO1996010413 19960411
- 主分类号： A61K9
- IPC分类号： A61K9 ; A61K38 ; A61K39 ; A61P37 ; C07K14
摘要：
Compositions with improved immunogenic effect are disclosed. The compositions contain one or more peptides which, when complexed with a cell surface molecule, such as an MHC, HLA or B cell receptor, provoke an immune response. The compositions contain adjuvants such as saponins, which potentiate the immune response. Especially preferred are compositions which stimulate cytolytic T cell responses, such as peptides which satisfy criteria for MHC binding, such as peptides derived from tumor rejection antigen precursors, including MAGE, BAGE, and GAGE derived peptides.
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