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公开(公告)号：EP1117679B1
公开(公告)日：2009-11-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
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2.发明授权ISOLATED NONAPEPTIDE DERIVED FROM MAGE-3 GENE AND PRESENTED BY HLA-A1, AND USES THEREOF 失效从MAGE-3基因的和HLA-A1-提出，隔离九肽及其应用
公开(公告)号：EP0658113B1
公开(公告)日：2004-10-20
申请号：EP93920419.4
申请日：1993-08-30
发明人： BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , DE PLAEN, Etienne , LURQUIN, Christophe , TRAVERSARI, Catia
IPC分类号： C07K14/705 , C07K16/30 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
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3.发明授权ISOLATED PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-C-CLONE 10 AND USES THEREOF 失效与MHCMULEKÜLHLA-C克隆10复杂的形式和用途分离的肽
公开(公告)号：EP0711173B1
公开(公告)日：2004-05-19
申请号：EP94920715.3
申请日：1994-06-10
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
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4.发明授权TUMOR REJECTION ANTIGENS PRESENTED BY HLA-B44 MOLECULES, AND USES THEREOF 失效由HLA-B44分子提呈肿瘤ABSTOSSUNGSANTIGENE及其用途
公开(公告)号：EP0854727B1
公开(公告)日：2001-11-21
申请号：EP96935876.1
申请日：1996-09-19
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/112 , G01N33/56977
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5.发明公开ISOLATED PEPTIDES WHICH COMPLEX WITH HLA-Cw*16 MOLECULES, AND USES THEREOF 失效分离的肽与HLA-CW * 16个分子复杂，其使用
公开(公告)号：EP0998299A1
公开(公告)日：2000-05-10
申请号：EP97940636.0
申请日：1997-08-27
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
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6.发明公开NUCLEIC ACID MOLECULE ENCODING A BIFUNCTIONAL PROTEIN, THE PROTEIN SO ENCODED AND USES THEREOF 失效甲双功能蛋白质的核酸分子编码，所述SO CODED蛋白及其用途
公开(公告)号：EP0935605A1
公开(公告)日：1999-08-18
申请号：EP97932619.0
申请日：1997-07-09
CPC分类号： G01N33/56977 , C07K14/4748 , G01N33/57492 , G01N2333/96466
摘要： The invention involves the identification of an isolated nucleic acid molecule which encodes a tumor rejection antigen. Various uses of this nucleic acid molecule and the protein it encodes are discussed.
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7.发明授权ISOLATED, MAGE-3 DERIVED PEPTIDES WHICH COMPLEX WITH HLA-A2 MOLECULES AND USES THEREOF 失效隔离MAGE-3的肽与HLA-A2分子复合物
公开(公告)号：EP0759032B1
公开(公告)日：1999-08-11
申请号：EP95914752.1
申请日：1995-03-21
CPC分类号： C07K16/30 , A61K38/00 , C07K14/4748 , Y10S530/828
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8.发明公开METHOD FOR IDENTIFYING AND TREATING INDIVIDUALS BEARING CANCER CELLS THAT EXPRESS HLA-C-CLONE 10/MAGE-1 失效FOR鉴定和个人处理方法中，癌细胞的载体为HLA-C-克隆10 / MAGE-1表达。
公开(公告)号：EP0680330A1
公开(公告)日：1995-11-08
申请号：EP94907261.0
申请日：1994-01-18
IPC分类号： G01N33 , A61K31 , A61K35 , A61K38 , A61K48 , A61K49 , A61P35 , C07K14 , C12N5 , C12N15 , C12Q1 , A61K39
CPC分类号： A61K48/00 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K14/70539
摘要： In the field of cancer diagnostics and therapy, the invention relates to the identification of abnormal cells which express complexes of HLA-C-Clone 10 MHC antigen and a peptide derived from MAGE-1, and cytolytic T cells which recognize and lyse the abnormal cells. Cloned cytolytic T cells which recognize the HLA-C-Clone 10/MAGE-1 complex may be used to identify individuals having cancer cells which express the complex. Also disclosed are methods for isolating the genes encoding HLA-C-Clone 10 and MAGE-1.
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公开(公告)号：EP2140247B1
公开(公告)日：2012-06-27
申请号：EP08726331.5
申请日：2008-03-03
CPC分类号： A61K31/7016 , A61K31/4745 , A61K45/06 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C12N5/0636 , C12N2500/22 , C12N2500/34 , C12N2501/59 , C12N2501/73 , G01N33/505 , A61K2300/00
摘要： The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity of the T lymphocyte is modulated.
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公开(公告)号：EP1119623B1
公开(公告)日：2009-04-01
申请号：EP99970121.2
申请日：1999-09-15
发明人： CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin, S. , VAN SNICK, Jacques , LETHE, Bernard , THIELEMANS, Kris , CORTHALS, Jurgen , HEIRMAN, Carlo
IPC分类号： C12N15/12 , C07K14/47 , G01N33/574 , C07K16/30 , C12N5/06
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4 T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
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