发明授权
- 专利标题： VERFAHREN ZUR DIAGNOSTISCHEN BEURTEILUNG UND VERLAUFSKONTROLLE SOWIE ARZNEIMITTEL ZUR THERAPIE VON SCHOCKZUSTÄNDEN BEIM MENSCHEN
- 专利标题（英）： Diagnosis and monitoring process, and medicaments for the therapy of states of shock in human beings
- 专利标题（中）： 程序进行诊断评估和开发控制及药物用于治疗休克状态在人类
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申请号： EP95935420.0申请日： 1995-09-30
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公开(公告)号： EP0786083B1公开(公告)日： 2000-08-09
- 发明人: BANG, Holger , BRUNE, Kay , WENDEL, Albrecht , TIEGS, Gesa
- 申请人： PAZ ARZNEIMITTEL- ENTWICKLUNGSGESELLSCHAFT MBH
- 申请人地址： In der Schildwacht 13 65933 Frankfurt DE
- 专利权人： PAZ ARZNEIMITTEL- ENTWICKLUNGSGESELLSCHAFT MBH
- 当前专利权人： PAZ ARZNEIMITTEL- ENTWICKLUNGSGESELLSCHAFT MBH
- 当前专利权人地址： In der Schildwacht 13 65933 Frankfurt DE
- 代理机构： Grussdorf, Jürgen, Dr.
- 优先权： DE4436352 19941012
- 国际公布： WO9612184 19960425
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12Q1/533
摘要：
A process is disclosed for detecting states of shock and for following the therapy of state of shock patients. For that purpose, the cyclophiline concentration in the patient's blood is determined by (a) enzymological methods, (b) immunological detection methods by means of specific antibodies, (c) peptidic chemical methods, (d) radiochemical methods, and is used to evaluate the severity of the state of shock. Also disclosed is the use of medicaments, biological active substances and physicochemical methods that reduce active cyclophiline concentration in the blood of state of shock patients for the therapy of states of shock, in particular septic shock, post-operative shock and toxic shock.
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