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1.发明授权
公开(公告)号：EP0786083B1
公开(公告)日：2000-08-09
申请号：EP95935420.0
申请日：1995-09-30
发明人： BANG, Holger , BRUNE, Kay , WENDEL, Albrecht , TIEGS, Gesa
CPC分类号： C12Q1/533 , G01N33/50 , Y10T436/106664
摘要： A process is disclosed for detecting states of shock and for following the therapy of state of shock patients. For that purpose, the cyclophiline concentration in the patient's blood is determined by (a) enzymological methods, (b) immunological detection methods by means of specific antibodies, (c) peptidic chemical methods, (d) radiochemical methods, and is used to evaluate the severity of the state of shock. Also disclosed is the use of medicaments, biological active substances and physicochemical methods that reduce active cyclophiline concentration in the blood of state of shock patients for the therapy of states of shock, in particular septic shock, post-operative shock and toxic shock.
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2.发明公开VERFAHREH ZUR DIAGNOSTISCHEN BEURTEILUNG UND VERLAUFSKONTROLLE SOWIE ARZNEIMITTEL ZUR THERAPIE VON SCHOCKZUSTÄNDEN BEIM MENSCHEN 失效VERFAHREH用于诊断评估和开发控制及药物用于治疗休克状态在人类
公开(公告)号：EP0786083A1
公开(公告)日：1997-07-30
申请号：EP95935420.0
申请日：1995-09-30
发明人： BANG, Holger , BRUNE, Kay , WENDEL, Albrecht , TIEGS, Gesa
CPC分类号： C12Q1/533 , G01N33/50 , Y10T436/106664
摘要： A process is disclosed for detecting states of shock and for following the therapy of state of shock patients. For that purpose, the cyclophiline concentration in the patient's blood is determined by (a) enzymological methods, (b) immunological detection methods by means of specific antibodies, (c) peptidic chemical methods, (d) radiochemical methods, and is used to evaluate the severity of the state of shock. Also disclosed is the use of medicaments, biological active substances and physicochemical methods that reduce active cyclophiline concentration in the blood of state of shock patients for the therapy of states of shock, in particular septic shock, post-operative shock and toxic shock.
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