发明公开
- 专利标题： MODIFIED FACTOR VII
- 专利标题（中）： 修饰的因子VII
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申请号： EP95938944.0申请日： 1995-10-24
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公开(公告)号： EP0789759A1公开(公告)日： 1997-08-20
- 发明人: BERKNER, Kathleen L. , PETERSEN, Lars Christian , HART, Charles E. , HEDNER, Ulla , BREGENGAARD, Claus
- 申请人： ZymoGenetics, Inc. , NOVO NORDISK A/S
- 申请人地址： 1201 Eastlake Avenue East Seattle Washington 98102 US
- 专利权人： ZymoGenetics, Inc.,NOVO NORDISK A/S
- 当前专利权人： ZymoGenetics, Inc.,NOVO NORDISK A/S
- 当前专利权人地址： 1201 Eastlake Avenue East Seattle Washington 98102 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US19940327690 19941024; US19950475845 19950607
- 国际公布： WO1996012800 19960502
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K38 ; A61P7 ; A61P9 ; A61P43 ; C12N9
摘要：
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.
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