发明授权
- 专利标题： IMPROVED PROCESSES FOR THE PREPARATION OF D-CHIRO-INOSITOL
- 专利标题（中）： 改进的方法生产D-手性肌醇
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申请号： EP95939080.8申请日： 1995-11-09
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公开(公告)号： EP0790970B1公开(公告)日： 1999-06-09
- 发明人: RILEY, David, A. , BHATIA, Ashok, V. , CHAMBERLIN, Steven, A. , ROBINSON, Gregg, E.
- 申请人： Abbott Laboratories
- 申请人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US337656 19941110; US539424 19951106
- 国际公布： WO9615088 19960523
- 主分类号： C07C29/10
- IPC分类号： C07C29/10 ; C07C35/16
摘要：
A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
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