公开(公告)号：EP1257531A2

公开(公告)日：2002-11-20

申请号：EP01916231.2

申请日：2001-02-23

申请人： Abbott Laboratories

发明人： BARKALOW, Jufang ,  CHAMBERLIN, Steven, A. ,  COOPER, Arthur, J. ,  HOSSAIN, Azad ,  HUFNAGEL, John, J. ,  LANGRIDGE, Denton, C.

IPC分类号： C07C327/02 ,  C07J31/00

CPC分类号： C07C327/02 ,  C07J31/003

摘要： This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

公开(公告)号：EP1154986A1

公开(公告)日：2001-11-21

申请号：EP00911908.2

申请日：2000-02-23

申请人： ABBOTT LABORATORIES

发明人： LORENZINI, Richard, A. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steven, A. ,  DRENGLER, Keith, A. ,  HUFNAGEL, John, J. ,  WANG, Xiu, C.

IPC分类号： C07C231/12 ,  C07C237/46

CPC分类号： C07C231/12 ,  C07C237/46

摘要： The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents.

公开(公告)号：EP1257531B1

公开(公告)日：2004-09-15

申请号：EP01916231.2

申请日：2001-02-23

申请人： Abbott Laboratories

发明人： BARKALOW, Jufang ,  CHAMBERLIN, Steven, A. ,  COOPER, Arthur, J. ,  HOSSAIN, Azad ,  HUFNAGEL, John, J. ,  LANGRIDGE, Denton, C.

IPC分类号： C07C327/02 ,  C07J31/00

CPC分类号： C07C327/02 ,  C07J31/003

摘要： This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

公开(公告)号：EP0790970B1

公开(公告)日：1999-06-09

申请号：EP95939080.8

申请日：1995-11-09

申请人： Abbott Laboratories

发明人： RILEY, David, A. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steven, A. ,  ROBINSON, Gregg, E.

IPC分类号： C07C29/10 ,  C07C35/16

CPC分类号： C07C69/013 ,  C07C29/095 ,  C07C35/16

摘要： A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

公开(公告)号：EP0882020B1

公开(公告)日：2001-04-11

申请号：EP97905920.1

申请日：1997-02-12

申请人： Abbott Laboratories

发明人： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

IPC分类号： C07D217/20

CPC分类号： C07D217/20

摘要： A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

公开(公告)号：EP0882020A1

公开(公告)日：1998-12-09

申请号：EP97905920.0

申请日：1997-02-12

申请人： Abbott Laboratories

发明人： CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

IPC分类号： C07D217

CPC分类号： C07D217/20

摘要： A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

公开(公告)号：EP0790970A1

公开(公告)日：1997-08-27

申请号：EP95939080.0

申请日：1995-11-09

申请人： Abbott Laboratories

发明人： RILEY, David, A. ,  BHATIA, Ashok, V. ,  CHAMBERLIN, Steven, A. ,  ROBINSON, Gregg, E.

IPC分类号： C07B61 ,  C07C27 ,  C07C29 ,  C07C35 ,  C07C67 ,  C07C69

CPC分类号： C07C69/013 ,  C07C29/095 ,  C07C35/16

摘要： A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.