发明公开
EP0796270A2 PEPTIDE COMPOUNDS FOR PREVENTION AND/OR TREATMENT OF NO-MEDIATED DISEASES
失效
肽类化合物为防止及/或治疗介导的疾病NO
- 专利标题: PEPTIDE COMPOUNDS FOR PREVENTION AND/OR TREATMENT OF NO-MEDIATED DISEASES
- 专利标题(中): 肽类化合物为防止及/或治疗介导的疾病NO
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申请号: EP95938602.0申请日: 1995-11-29
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公开(公告)号: EP0796270A2公开(公告)日: 1997-09-24
- 发明人: ITOH, Yoshikuni , IWAMOTO, Toshiro , YATABE, Takumi , HAMASHIMA, Hitoshi , INOUE, Takayuki , HASHIMOTO, Seiji , OKU, Teruo
- 申请人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址: 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541 JP
- 专利权人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人: FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541 JP
- 代理机构: Gille, Christian, Dipl.-Ing., et al
- 优先权: GB19940024408 19941202; GB19950004891 19950310; GB19950010042 19950518
- 国际公布: WO1996016981 19960606
- 主分类号: A61K38
- IPC分类号: A61K38 ; A61P3 ; A61P9 ; A61P11 ; A61P13 ; A61P15 ; A61P25 ; A61P27 ; A61P29 ; A61P43 ; C07K5
摘要:
New peptide compounds of formula (I) wherein W is a group of formula (a) [in which R1 is hydrogen, halogen, lower alkyl, etc., Q is CH or N, L is a bivalent radical (b) (in which Y is CH or N, Z is NH, O or S, and --- is a single bond or a double bond), etc.,], etc., A1 is lower alkylene, -NHCO-, (c) (in which V is O or S), or -SO¿2?-, T is hydrogen, aryl which may have suitable substituent(s), heterocyclic group, hydroxy, etc., A?2¿ is lower alkylene, R8 is hydrogen or lower alkyl, etc., R3 is hydrogen, aryl which may have suitable substituent(s), hydroxy, protected hydroxy, etc., A3 is bond or lower alkylene, R9 is hydrogen or lower alkyl, etc., and R4 is carboxy, protected carboxy, heterocycliccarbonyl which may have suitable substituent(s), or a group of formula (d) (in which R5 is hydrogen or lower alkyl, and R6 is hydrogen, aryl, ar(lower)alkyl which may have suitable substituent(s), etc.), etc., and a pharmaceutically acceptable salt thereof which are useful as a medicament.
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