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公开(公告)号：EP0933422A1
公开(公告)日：1999-08-04
申请号：EP97926214.4
申请日：1997-06-11
发明人： UEDA, Satoshi , TANAKA, Miho , EZAKI, Masami , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , OOHATA, Nobutaka , TSUBOI, Masaru , YAMASHITA, Michio
摘要： The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
[wherein R 1 is acyl;
R 2 is hydroxy or acyloxy;
R 3 is hydrogen or hydroxy;
R 4 is hydrogen or hydroxy;
R 5 is hydrogen or hydroxysulfonyloxy; and
R 6 is hydrogen or carbamoyl]摘要翻译： 本发明提供了一种环状脂肽酰基转移酶，其可以有效地脱酰化环状脂肽化合物的酰基侧链，特别是FR901379由以下通式ⅪI所示的物质或其类似物，以及一种环肽化合物的制备方法， 使用所述酰基转移酶。 其中R 1是酰基; R 2是羟基或酰氧基; R 3是氢或羟基; R 4是氢或羟基; R 5是氢或羟基磺酰氧基; R 6是氢或氨基甲酰基
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2.发明公开PROCESS FOR THE DEACYLATION OF CYCLIC LIPOPEPTIDES 失效PROZESSFÜRDIE DEACYLIERUNG VON ZYKLISCHEN LIPOPEPTIDEN。
公开(公告)号：EP0885957A1
公开(公告)日：1998-12-23
申请号：EP97905455.8
申请日：1997-03-06
发明人： UEDA, Satoshi , TANAKA, Miho , EZAKI, Masami , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , OOHATA, Nobutaka , TSUBOI, Masaru , YAMASHITA, Michio
IPC分类号： C12N9/80
摘要： There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.
[wherein R 1 is acyl;
R 2 is hydroxy or acyloxy;
R 3 is hydrogen or hydroxy;
R 4 is hydrogen or hydroxy;
R 5 is hydrogen or hydroxysulfonyloxy; and
R 6 is hydrogen or carbamoyl.]摘要翻译： 提供了环状脂肽酰基转移酶，其能够使环状脂肽化合物的酰基侧链脱酰化，例如， 具有以下通式的物质FR901379或其类似物，其有效性以及包含使用酰基转移酶的环肽化合物的制备方法。 其中R 1是酰基; R 2是羟基或酰氧基; R 3是氢或羟基; R 4是氢或羟基; R 5是氢或羟基磺酰氧基; 和R 6是氢或氨基甲酰基
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3.发明公开SUBSTANCE WF16616, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF 失效SUBSTANZ WF16616，HERSTELLUNGSPROZESS UND VERWENDUNG
公开(公告)号：EP0846699A1
公开(公告)日：1998-06-10
申请号：EP96918875.4
申请日：1996-06-21
摘要： WF16616 substance represented by the following structural formula (1) or its pharmaceutically acceptable salt.
WF16616 substance exhibits an antimicrobial activity, especially an excellent antifungal activity.摘要翻译： WF16616物质由下述结构式（1）表示，或其药学上可接受的盐。
WF16616物质表现出抗菌活性，特别是优异的抗真菌活性。 -
公开(公告)号：EP0983297A1
公开(公告)日：2000-03-08
申请号：EP98919630.8
申请日：1998-05-18
发明人： HORI, Yasuhiro , TSURUMI, Yasuhisa , TAKASE, Shigehiro , HATANAKA, Hiroshi , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , OHKI, Hidenori , TOJO, Takashi , MATSUDA, Keiji , KAWABATA, Kohji
摘要： The invention relates to new polypeptide compounds represented by formula (I), wherein R1 is hydrogen, etc., R2 is hydrogen, etc., R3 is hydrogen, etc., and R4 is hydrogen, etc., or a salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia in a human being or an animal.
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公开(公告)号：EP0817796A1
公开(公告)日：1998-01-14
申请号：EP96906942.0
申请日：1996-03-26
摘要： New peptide compounds of formula (I), wherein R1 is alkyl or aralkyl, R2 is amino(lower)alkyl or protected amino(lower)alkyl, R3 is hydroxy, protected hydroxy, amino or protected amino, R4 is hydroxy, or R?3 and R4¿ are linked together to form -Z- (in which -Z- is -O- or -NH-), and R5 is hydrogen or an amino protective group, R6 is hydroxy, or R?5 and R6¿ are linked together to form bond, with proviso that when R3 is hydroxy, protected hydroxy, amino or protected amino and R4 is hydroxy, then R?5 and R6¿ are linked together to form bond, and a pharmaceutically acceptable salt thereof, which is useful as a medicament.
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6.发明公开PROCESS FOR PREPARING FR900482 AND COMPOUNDS ANALOGOUS THERETO 失效VERFAHREN ZUR HERSTELLUNG VON FR900482 UND ANALOGE VERBINDUNGEN
公开(公告)号：EP0943689A1
公开(公告)日：1999-09-22
申请号：EP97909655.9
申请日：1997-10-28
CPC分类号： C12P17/188 , Y10S435/929
摘要： A process for preparing compounds represented by general formula (I), wherein R 1 represent hydrogen, a lower alkanoyl group or a lower alkyl group; and R 2 and R 3 represent each hydrogen or a lower alkanoyl group, characterized by reacting a culture of a strain belonging to the genus Fusarium or cells obtained by the filtration of the culture with a compound represented by general formula (II) wherein R 1 , R 2 , and R 3 are each as defined above.
摘要翻译： 一种制备由通式（I）表示的化合物的方法，其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3代表每个氢或低级烷酰基，其特征在于使属于镰刀菌属的菌株的培养物或通过过滤培养物得到的细胞与通式（II）表示的化合物反应 ）其中R 1，R 2和R 3各自如上所定义。
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公开(公告)号：EP0941237A1
公开(公告)日：1999-09-15
申请号：EP97912495.0
申请日：1997-11-18
发明人： KANASAKI, Ryuichi , TAKASE, Shigehiro , HASHIMOTO, Michizane , HATANAKA, Hiroshi , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , SHIRAISHI, Nobuyuki , OHKI, Hidenori , KAWABATA, Kohji
摘要： This invention relates to new polypeptide compounds represented by formula (I), wherein R1 is as defined in the description or a salt thereof, which have antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to a process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
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8.发明公开
公开(公告)号：EP0796270A2
公开(公告)日：1997-09-24
申请号：EP95938602.0
申请日：1995-11-29
发明人： ITOH, Yoshikuni , IWAMOTO, Toshiro , YATABE, Takumi , HAMASHIMA, Hitoshi , INOUE, Takayuki , HASHIMOTO, Seiji , OKU, Teruo
IPC分类号： A61K38 , A61P3 , A61P9 , A61P11 , A61P13 , A61P15 , A61P25 , A61P27 , A61P29 , A61P43 , C07K5
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06043 , C07K5/0606 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/06113 , C07K5/06139 , C07K5/06147
摘要： New peptide compounds of formula (I) wherein W is a group of formula (a) [in which R1 is hydrogen, halogen, lower alkyl, etc., Q is CH or N, L is a bivalent radical (b) (in which Y is CH or N, Z is NH, O or S, and --- is a single bond or a double bond), etc.,], etc., A1 is lower alkylene, -NHCO-, (c) (in which V is O or S), or -SO¿2?-, T is hydrogen, aryl which may have suitable substituent(s), heterocyclic group, hydroxy, etc., A?2¿ is lower alkylene, R8 is hydrogen or lower alkyl, etc., R3 is hydrogen, aryl which may have suitable substituent(s), hydroxy, protected hydroxy, etc., A3 is bond or lower alkylene, R9 is hydrogen or lower alkyl, etc., and R4 is carboxy, protected carboxy, heterocycliccarbonyl which may have suitable substituent(s), or a group of formula (d) (in which R5 is hydrogen or lower alkyl, and R6 is hydrogen, aryl, ar(lower)alkyl which may have suitable substituent(s), etc.), etc., and a pharmaceutically acceptable salt thereof which are useful as a medicament.
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