发明公开
EP0808319A1 DERIVES TRIARYLOXYACETYL D'EPIPODOPHYLLOTOXINES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS ANTICANCEREUX
失效
TRIARYLOXYACETYL衍生物技术鬼臼乙叉甙，用于生产及其用作抗恶性肿瘤药
- 专利标题： DERIVES TRIARYLOXYACETYL D'EPIPODOPHYLLOTOXINES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS ANTICANCEREUX
- 专利标题（英）： Epipodophyllotoxin triaryloxyacetyl derivatives, method for preparing same, and use of said derivatives as cancer drugs
- 专利标题（中）： TRIARYLOXYACETYL衍生物技术鬼臼乙叉甙，用于生产及其用作抗恶性肿瘤药
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申请号： EP96903064.0申请日： 1996-02-07
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公开(公告)号： EP0808319A1公开(公告)日： 1997-11-26
- 发明人: IMBERT, Thierry , GUMINSKI, Yves , COLPAERT, Francis , TARAYRE, Jean-Pierre , HILL, Bridget
- 申请人： PIERRE FABRE MEDICAMENT
- 申请人地址： 45, Place Abel Gance 92100 Boulogne FR
- 专利权人： PIERRE FABRE MEDICAMENT
- 当前专利权人： PIERRE FABRE MEDICAMENT
- 当前专利权人地址： 45, Place Abel Gance 92100 Boulogne FR
- 代理机构： Le Forestier, Eric
- 优先权： FR19950001433 19950208
- 国际公布： WO1996024602 19960815
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P35 ; C07H17
摘要：
Derivatives of general formula (I), wherein R' is methyl or 2-thienyl, R is an acyl group of formula R1OCH2CO, wherein R1 is a phenyl ring ortho-, meta- or para-substituted by one or more substituents X, where X is a formyl, acetyl, cyano or trifluoroacetyl group, and pharmaceutically acceptable salts thereof, are disclosed. A method for preparing said derivatives, their use as a drug, and pharmaceutical compositions containing them, are also disclosed.
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