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    DERIVES DE DIHYDRO-1,2 OXO-2 QUINOXALINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    6.
    发明授权
    DERIVES DE DIHYDRO-1,2 OXO-2 QUINOXALINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 失效
    DERIVES DE DIHYDRO-1,2 OXO-2 QUINOXALINES，LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUQUE

    公开(公告)号：EP0450039B1

    公开(公告)日：1996-06-05

    申请号：EP90916034.3

    申请日：1990-10-17

    申请人： PIERRE FABRE MEDICAMENT

    发明人： PITET, Guy ,  FAURE, Christian ,  COURET, Françoise ,  BIGG, Dennis ,  TARAYRE, Jean-Pierre

    IPC分类号： C07D241/44 ,  C07D401/06 ,  A61K31/495

    CPC分类号： C07D401/06 ,  C07D241/44

    摘要： Novel dihydro-1,2 oxo-2 quinoxaline derivates corresponding to general formula (I) in which R represents a hydrogen or halogen atom; R1 represents a hydrogen atom or C1-C4 alkyl radical, linear or branched; R2 represents: a hydrogen atom, a C(O)R4 radical where R4 is C1-C4 alkyl group, linear or branched, a C(O)NHR4 radical where R5 is C1-C4 alkyl group linear or branched, or a phenyl group; A represents C1-C4 alkylene chain; R3 represents a hydrogen atom, C1-C4 alkyl radical, C3-C6 cycloalkyl radical, an alkynyl, nitril, hydroxyl, carboxamido, pyridyl, phenyl group or a phenyl substituted by a halogen atom, C1-C4 alkyl group, C1-C4 alkoxy group, or a nitro group; an alkenyl radical of formula (α) where R6, R7 can, independently of each other, be a hydrogen atom, C1-C4 alkyl group, a phenyl group, or an alkoxycarbonyl group; a radical of the formula -OC(O)R8, where R8 represents C1-C4 alkyl radical; a radical of the formula -OC(O)NHR9, where R9 represents C1-C4 alkyl radical, linear or branched, or a phenyl group; n can take values from 2 to 4, as well as the organic or mineral salts of said molecules which are therapeutically acceptable.

    摘要翻译： 新的对应于通式（I）的二氢-1,2-氧代-2-喹喔啉衍生物其中R代表氢或卤素原子; R1代表氢原子或C1-C4烷基，直链或支链; R2表示：氢原子，其中R4为C1-C4烷基的C（O）R4基团，直链或支链的，C（O）NHR4基团，其中R5为C1-C4直链或支链烷基或苯基 ; A代表C1-C4亚烷基链; R3代表氢原子，C1-C4烷基，C3-C6环烷基，炔基，腈基，羟基，甲酰氨基，吡啶基，苯基或被卤素原子取代的苯基，C1-C4烷基，C1- 基团或硝基; （α）的链烯基，其中R6，R7可以彼此独立地为氢原子，C1-C4烷基，苯基或烷氧基羰基; 式-OC（O）R 8的基团，其中R 8代表C 1 -C 4烷基; 式-OC（O）NHR9的基团，其中R9代表C1-C4烷基，直链或支链或苯基; n可以取2至4的值，以及所述治疗上可接受的分子的有机或无机盐。