发明公开
- 专利标题： TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES
- 专利标题（中）： 三环衍生物如适用G-蛋白抑制剂和增生性疾病的治疗
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申请号： EP96912469.0申请日： 1996-04-03
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公开(公告)号： EP0819121A1公开(公告)日： 1998-01-21
- 发明人: AFONSO, Adriano , BALDWIN, John, J. , DOLL, Ronald, J. , LI, Ge , MALLAMS, Alan, K. , NJOROGE, F., George , RANE, Dinanath, F. , READER, John, C. , ROSSMAN, Randall, R.
- 申请人： SCHERING CORPORATION , PHARMACOPEIA, INC.
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Ritter, Stephen David, et al
- 优先权： US19950418323 19950407
- 国际公布： WO1996031478 19961010
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P35 ; A61P43 ; C07D221 ; C07D401 ; C07D491
摘要：
Novel compounds of Formula (1.0) are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
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