The invention concerns a measurement device (1) for measuring or investigating physiological parameters using biological cells or chemical and biologically active substances contained in an analyte (2). The measurement device comprises a sensor (4) with an electronic measurement structure (6) located on a substrate (5). Function-specific receptor- and/or target cells (7) form part of the sensor (4) and are in direct contact with the measurement structure (6). The medium under investigation can be brought into contact with the target or receptor cells (7). The measurement device (1) is especially compact in its design and facilitates largely feedback-free investigation of biological or chemical components contained in the analyte.