发明公开
- 专利标题： CONNECTIVE TISSUE GROWTH FACTOR
- 专利标题（中）： 结缔组织生长因子（CTGF）
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申请号： EP96916841.0申请日： 1996-05-31
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公开(公告)号： EP0831903A1公开(公告)日： 1998-04-01
- 发明人: GROTENDORST, Gary, R. , BRADHAM, Douglass, M., Jr.
- 申请人： UNIVERSITY OF SOUTH FLORIDA
- 申请人地址： 4202 Fowler Avenue Tampa, FL 33620-6250 US
- 专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人地址： 4202 Fowler Avenue Tampa, FL 33620-6250 US
- 代理机构： Jaenichen, Hans-Rainer, Dr.
- 优先权： US19950459717 19950602
- 国际公布： WO1996038172 19961205
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K31 ; A61K38 ; A61K39 ; A61K45 ; A61K48 ; A61P9 ; A61P11 ; A61P13 ; A61P17 ; A61P27 ; A61P35 ; A61P43 ; C07K14 ; C12N5 ; C12Q1 ; G01N33
摘要：
The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF-β responsive element upstream of the polynucleotide encoding CTGF structural gene.
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