公开(公告)号：EP0748219B1

公开(公告)日：2005-04-06

申请号：EP95910239.3

申请日：1995-02-09

申请人： Sugen, Inc. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： GAZIT, Aviv ,  LEVITZKI, Alexander ,  APP, Harald ,  TANG, Cho, Peng ,  MCMAHON, Gerald, M.

IPC分类号： A61K31/24 ,  A61K31/42 ,  A61K31/275 ,  A61K31/415 ,  A61K31/495 ,  C07C211/45 ,  C07C255/01 ,  C07D209/18 ,  C07D231/38 ,  C07D241/36 ,  C07C255/41 ,  C07D239/93

CPC分类号： C07D487/04 ,  A61K31/235 ,  A61K31/275 ,  A61K31/277 ,  A61K31/38 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/495 ,  A61K31/502 ,  A61K31/505 ,  A61K31/517 ,  A61K31/535 ,  A61K38/00 ,  C07C229/60 ,  C07C255/36 ,  C07C255/40 ,  C07C255/41 ,  C07C255/66 ,  C07C317/46 ,  C07C327/44 ,  C07D209/18 ,  C07D239/93 ,  C07D239/94 ,  C07D241/42 ,  C07D241/44 ,  C07K14/71 ,  C07K16/2863 ,  C07K2319/32 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5064 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2333/71 ,  G01N2500/04

摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is based, in part, on the demonstration that KDR/FLK-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of FLK-1. These results indicate a major role for KDR/FLK-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express FLK-1 and the uses of expressed FLK-1 to evaluate and screen for drugs and analogs of VEGF involved in FLK-1 modulation by either agonist or antagonist activities is also described. The invention also relates to the use of the disclosed compounds in the treatment of disorders, including cancer, diabetes, hemangioma and Kaposi's sarcoma, which are related to vasculogenesis and angiogenesis.

公开(公告)号：EP0505012B2

公开(公告)日：2004-01-21

申请号：EP92201244.8

申请日：1986-03-27

申请人： F. HOFFMANN-LA ROCHE AG

发明人： Mullis, Kary Banks

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12N15/10

CPC分类号： C12N15/10 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00722 ,  B01L7/52 ,  C07K14/805 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/689 ,  C40B40/06 ,  C40B60/14 ,  C12Q2525/131 ,  C12Q2521/513

公开(公告)号：EP0657532B1

公开(公告)日：2003-12-17

申请号：EP94110658.5

申请日：1988-06-09

申请人： N.V. INNOGENETICS S.A.

发明人： Deleys, Robert, c/o Innogenetics N.V. ,  Vanderborght, Bart, c/o Innogenetics N.V. ,  Saman, Eric, c/o Innogenetics N.V. ,  Van Heuverswyn, Hugo, c/o Innogenetics N.V.

IPC分类号： C12N7/00 ,  C07K14/16 ,  G01N33/569 ,  C12Q1/70 ,  C12Q1/68

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/1045 ,  C07K16/1054 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12N2740/16222 ,  G01N33/56988 ,  G01N2333/16 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S530/809

公开(公告)号：EP1036844A1

公开(公告)日：2000-09-20

申请号：EP98955971.1

申请日：1998-11-27

申请人： Chugai Research Institute for Molecular Medicine Inc.

发明人： JENNE, Dieter, E. ,  NEZU, Jun-ichi, Chugai Res.Inst. Molec. Medic.Inc.

IPC分类号： C12N15/12 ,  C12N15/54 ,  C12N15/63 ,  C12Q1/68 ,  C07K16/40 ,  A61K48/00 ,  A61K38/43 ,  A61K33/32

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C12Q1/6883 ,  C12Q2600/156

摘要： With respect to a range of 1.5 Mbp and more in the chromosome 19p13.3 region containing Peutz-Jeghers gene, a continuous cosmid contig is constructed and a restriction map is prepared. Next, genes mapped with this region are searched by using EST database and the locations of these genes are accurately determined. Based on the evaluation of biological data, etc., several highly likely candidates for Peutz-Jeghers genes are specified from the genes thus found. After successively analyzing variations in these genes in DNAs of patients with Peutz-Jeghers syndrome, it is found that one of these genes, i.e., "LKB1" has been specifically varied in these patients. Thus, the diseases caused by the variation in the LKB1 gene can be diagnosed and treated by using the LKB1 gene, primers and probes based on its base sequence, LKB1 protein, an antibody biding to this protein, etc.

公开(公告)号：EP0248819B2

公开(公告)日：2000-08-30

申请号：EP86905648.1

申请日：1986-09-11

申请人： Scios Inc.

发明人： FIDDES, John, C. ,  ABRAHAM, Judith, A.

IPC分类号： C12P21/02 ,  C12N15/18 ,  C07K14/50

CPC分类号： C07K14/503 ,  A61K38/00 ,  C07K14/501 ,  C12N15/67

摘要： The DNA sequences encoding human and bovine acidic and basic fibroblast growth factors (FGF) can be recombinantly expressed to obtain practical amounts of proteins useful in effecting wound healing and related tissue repair.

公开(公告)号：EP0666864B1

公开(公告)日：1999-11-24

申请号：EP92921979.8

申请日：1992-10-07

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  SELLERI, Licia 201 Fourth Street ,  EUBANKS, James, H.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q1/6876 ,  C12Q2600/156

公开(公告)号：EP0833894A1

公开(公告)日：1998-04-08

申请号：EP96921491.0

申请日：1996-06-07

申请人： ARIAD GENE THERAPEUTICS, INC.

发明人： CLACKSON, Timothy ,  HOLT, Dennis, A. ,  GILMAN, Michael, Z.

IPC分类号： C07K14 ,  C12N9 ,  C12N15 ,  A61K48

摘要： This invention concerns new configurations for biological switches and provides new methods and materials useful for regulating biological events in animal cells. The invention involves recombinant DNA constructs comprising DNA sequences derived from sequences encoding the proteins FRAP, Tor1, Tor2 and other proteins capable of binding to FKBP:rapamycin, other recombinant DNA constructs comprising DNA sequences encoding part or all of an FKBP protein, the proteins encoded by those constructs, cells (especially animal cells) transformed with one or more of the constructs, small molecules (multivalent multimerizing agents) which bind to and are capable of inducing multimerization of the chimeric proteins, and methods for preparing and using the foregoing.

公开(公告)号：EP0666864A1

公开(公告)日：1995-08-16

申请号：EP92921979.0

申请日：1992-10-07

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  SELLERI, Licia 201 Fourth Street ,  EUBANKS, James, H.

IPC分类号： G01N33 ,  C07H21 ,  C12Q1

CPC分类号： C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q1/6876 ,  C12Q2600/156

摘要： Nucleotide sequence defining a polymorphic locus useful for identification of an individual. Also disclosed are oligonucleotide primers useful in amplification of the locus and methods for detecting the amplified locus.

公开(公告)号：EP0471011B1

公开(公告)日：1994-10-12

申请号：EP90907718.2

申请日：1990-04-27

申请人： BAYLOR COLLEGE OF MEDICINE

发明人： HEADON, Denis, R. Lishin, Aghnacurra ,  CONNEELY, Orma, M. ,  O'MALLEY, Bert, W.

IPC分类号： C12N15/12

CPC分类号： C07K14/79

摘要： The verified cDNA sequence for human lactoferrin (hLF) protein has been discovered. The cDNA sequence can be used to prepare recombinant human lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product.

公开(公告)号：EP0472708B1

公开(公告)日：1994-08-24

申请号：EP91906410.5

申请日：1991-03-16

申请人： New York Blood Center, Inc.

发明人： WOLTER, Dieter ,  SCHWINN, Horst

IPC分类号： A61K35/16 ,  A61L2/18 ,  C07K3/20 ,  B01D15/08

CPC分类号： A61L2/0088 ,  A61K35/16

摘要： In a process for producing non-infectious blood plasma, the plasma is treated with non-ionic tensides, the lipid phase is separated and the non-ionic tenside is removed by solid-phase extraction on hydrophobic materials.