发明公开
EP0852225A4 FIBRINOGEN RECEPTOR ANTAGONISTS AND MEDICINAL PREPARATIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
失效
纤维蛋白原受体拮抗剂和医疗机构制剂有诸如活性成分含
- 专利标题: FIBRINOGEN RECEPTOR ANTAGONISTS AND MEDICINAL PREPARATIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
- 专利标题(中): 纤维蛋白原受体拮抗剂和医疗机构制剂有诸如活性成分含
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申请号: EP97928513申请日: 1997-06-27
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公开(公告)号: EP0852225A4公开(公告)日: 1998-10-07
- 发明人: HAYASHI YOSHIO , HARADA TAKEO , TACHIKI AKIRA , KATADA JUN
- 申请人: NIPPON STEEL CORP
- 专利权人: NIPPON STEEL CORP
- 当前专利权人: NIPPON STEEL CORP
- 优先权: JP16798296 1996-06-27
- 主分类号: C07D295/10
- IPC分类号: C07D295/10 ; A61K31/4427 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61K31/5375 ; A61K31/54 ; A61K31/55 ; A61P7/00 ; A61P7/02 ; A61P9/00 ; A61P43/00 ; C07D211/34 ; C07D211/46 ; C07D211/74 ; C07D401/12 ; C07D405/06 ; C07D413/12 ; C07D417/12 ; C07D211/62 ; C07D295/18 ; C07D295/20
摘要:
Compounds represented by general formula (I) and medicinal preparations, in particular, platelet aggregation inhibitors, blood coagulation inhibitors for systemic circulation, and coronary reinfarction inhibitors, wherein A represents a tertiary amine; R3 represents hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower aralkyl, or aryl; R4 represents hydrogen, optionally substituted lower alkyl, lower alkenyl, lower alkynyl, optionally substituted lower aralkyl, optionally substituted lower aralkenyl, optionally substituted lower aralkynyl, optionally substituted aryl, optionally substituted heterocycle, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted cycloalkynyl or lower alkoxy; P and Q represent each lower alkyl or P and Q are combined to form cycloalkyl together with the adjacent carbon atom; R5 represents hydrogen or a carboxy-protective group; X represents nitrogen or CH; Y1 and Y2 represent each hydrogen, lower alkyl, halogeno, hydroxy, lower alkoxy, lower acyloxy, acyl, carboxy, lower alkoxycarbonyl, nitro or trifluoromethyl; and m is an integer of 0 to 2.
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